Autoimmune pathogenesis in dengue virus infection

Chiou Feng Lin, Shu Wen Wan, Hsien Jen Cheng, Huan Yao Lei, Yee Shin Lin

研究成果: 雜誌貢獻文章同行評審

109 引文 斯高帕斯(Scopus)

摘要

The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved. Patients with DHF/DSS are characterized by several manifestations, including severe thrombocytopenia, vascular leakage, and hepatomegaly. In addition to the effect of virus load and virus variation, abnormal immune responses of the host after DV infection may also account for the progression of DHF/DSS. Actually, viral autoimmunity is involved in the pathogenesis of numerous viral infections, such as human immunodeficiency virus, human hepatitis C virus, human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, and DV. In this review, we discuss the implications of autoimmunity in dengue pathogenesis. Antibodies directed against DV noiistructural protein 1 (NS1) showed cross-reactivity with human platelets and endothelial cells, which lead to platelet and endothelial' cell damage and inflammatory activation. Based on these findings, we hypothesize that anti-BV NS1 is involved in the pathogenesis of DF and DHF/DSS, and this may provide important information in dengue vaccine development.

原文英語
頁(從 - 到)127-132
頁數6
期刊Viral Immunology
19
發行號2
DOIs
出版狀態已發佈 - 2006
對外發佈

ASJC Scopus subject areas

  • 免疫學
  • 病毒學

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