摘要
Thymic interleukin-6 (IL-6), which is produced primarily by thymic epithelial cells, is an important cytokine for T cell growth and differentiation in the thymus. In the present study, we investigated the effects of autocrine IL-6 on the cytokines in primary cultures of human thymic epithelial cells. Using an antibody array and ELISA, in addition to IL-8 and MCP-1, growth-related oncogene-α (GRO-α) was subsequently expressed after IL-6 production. Either IL-6 or GRO-α was time-dependently and strongly expressed in medium with and without serum. Neutralizing IL-6 significantly reduced GRO-α production. Inhibiting Janus kinase 2 (Jak2) spontaneously blocked GRO-α production with or without IL-6 stimulation. We conclude that primary human thymic epithelial cells produce GRO-α and that its expression is regulated primarily by autocrine IL-6 and IL-6-activated Jak2 signaling.
原文 | 英語 |
---|---|
頁(從 - 到) | 195-201 |
頁數 | 7 |
期刊 | Cytokine |
卷 | 51 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 八月 2010 |
對外發佈 | Yes |
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Hematology
- Biochemistry
- Molecular Biology
- Medicine(all)