Autocrine IL-6 regulates GRO-α production in thymic epithelial cells

Yau Lin Tseng, Ming Ho Wu, Hsin Chiao Yang, Chi Yun Wang, Chiou Feng Lin

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Thymic interleukin-6 (IL-6), which is produced primarily by thymic epithelial cells, is an important cytokine for T cell growth and differentiation in the thymus. In the present study, we investigated the effects of autocrine IL-6 on the cytokines in primary cultures of human thymic epithelial cells. Using an antibody array and ELISA, in addition to IL-8 and MCP-1, growth-related oncogene-α (GRO-α) was subsequently expressed after IL-6 production. Either IL-6 or GRO-α was time-dependently and strongly expressed in medium with and without serum. Neutralizing IL-6 significantly reduced GRO-α production. Inhibiting Janus kinase 2 (Jak2) spontaneously blocked GRO-α production with or without IL-6 stimulation. We conclude that primary human thymic epithelial cells produce GRO-α and that its expression is regulated primarily by autocrine IL-6 and IL-6-activated Jak2 signaling.

原文英語
頁(從 - 到)195-201
頁數7
期刊Cytokine
51
發行號2
DOIs
出版狀態已發佈 - 八月 2010
對外發佈

ASJC Scopus subject areas

  • 免疫學
  • 免疫學和過敏
  • 血液學
  • 生物化學
  • 分子生物學
  • 醫藥 (全部)

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