Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjögren's Syndrome

Wei Sheng Chen, Kuan Chia Lin, Chun Hsiung Chen, Hsien-Tzung Liao, Hon Pin Wang, Wing Y. Li, Hui Ting Lee, Chang Youh Tsai, Chung Tei Chou

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

Objective. Sjögren's syndrome (SS) is an inflammatory autoimmune disease.We investigated important factors associated with the expression of inflammation-related molecules in minor salivary gland (MSG) mononuclear cells in patients with SS. Methods. Thirty-four patients with SS with a MSG biopsy grading of either grade III (10 patients) or grade IV (24 patients) were enrolled. The age, sex, autoantibodies, cell infiltration, and intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-3 (MMP-3), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), or CXCR3 expression were also analyzed. Results. Ten of the 34 patients with SS were diagnosed with secondary SS; in these patients, the diagnosis of rheumatoid arthritis was confirmed in 8 and systemic lupus erythematosus in 2. TRAIL and ICAM-1 were overexpressed in patients with antinuclear antibodies (ANA) > 1:160, compared to those with titer <1:160 (45.1 ± 4.4 vs 41.2 ± 3.9, p = 0.021, and 15.2 ± 5.7 vs 10.8 ± 3.3, p = 0.018, respectively). Higher erythrocyte sedimentation rate (ESR; ≥ 20) was associated with higher TRAIL expression and CD20 cell infiltration in contrast to lower ESR (<20; p <0.05). ICAM-1, TRAIL, and MMP-3 were expressed more predominantly in anti-SSA-positive than in anti-SSA-negative patients with SS. There was a significant difference in CD20 cell infiltration and MMP-3 expression between primary SS and secondary SS. Biopsy of a grade IV showed a significantly increased expression of TRAIL (44.9 ± 4.5 vs 40.8 ± 3.6, p = 0.013) and MMP-3 (62.7 ± 6.3 vs 54.4 ± 7.3, p = 0.003) in mononuclear cells as compared to those of grade III. Conclusion. In our study, pathologic grading with a higher grade (grade IV) and the presence of SSA or a higher titer of ANA were significantly associated with the overexpression of TRAIL, MMP-3, or ICAM-1 in the salivary gland mononuclear cells in patients with SS. The Journal of Rheumatology
原文英語
頁(從 - 到)989-996
頁數8
期刊Journal of Rheumatology
36
發行號5
DOIs
出版狀態已發佈 - 五月 2009

指紋

Matrix Metalloproteinase 3
Intercellular Adhesion Molecule-1
Salivary Glands
Autoantibodies
Biopsy
Minor Salivary Glands
Antinuclear Antibodies
Blood Sedimentation
Cell Adhesion Molecules
Rheumatology
Systemic Lupus Erythematosus
Autoimmune Diseases
Rheumatoid Arthritis
Tumor Necrosis Factor-alpha
Apoptosis
Ligands
Inflammation

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

引用此文

Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjögren's Syndrome. / Chen, Wei Sheng; Lin, Kuan Chia; Chen, Chun Hsiung; Liao, Hsien-Tzung; Wang, Hon Pin; Li, Wing Y.; Lee, Hui Ting; Tsai, Chang Youh; Chou, Chung Tei.

於: Journal of Rheumatology, 卷 36, 編號 5, 05.2009, p. 989-996.

研究成果: 雜誌貢獻文章

Chen, Wei Sheng ; Lin, Kuan Chia ; Chen, Chun Hsiung ; Liao, Hsien-Tzung ; Wang, Hon Pin ; Li, Wing Y. ; Lee, Hui Ting ; Tsai, Chang Youh ; Chou, Chung Tei. / Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjögren's Syndrome. 於: Journal of Rheumatology. 2009 ; 卷 36, 編號 5. 頁 989-996.
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title = "Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sj{\"o}gren's Syndrome",
abstract = "Objective. Sj{\"o}gren's syndrome (SS) is an inflammatory autoimmune disease.We investigated important factors associated with the expression of inflammation-related molecules in minor salivary gland (MSG) mononuclear cells in patients with SS. Methods. Thirty-four patients with SS with a MSG biopsy grading of either grade III (10 patients) or grade IV (24 patients) were enrolled. The age, sex, autoantibodies, cell infiltration, and intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-3 (MMP-3), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), or CXCR3 expression were also analyzed. Results. Ten of the 34 patients with SS were diagnosed with secondary SS; in these patients, the diagnosis of rheumatoid arthritis was confirmed in 8 and systemic lupus erythematosus in 2. TRAIL and ICAM-1 were overexpressed in patients with antinuclear antibodies (ANA) > 1:160, compared to those with titer <1:160 (45.1 ± 4.4 vs 41.2 ± 3.9, p = 0.021, and 15.2 ± 5.7 vs 10.8 ± 3.3, p = 0.018, respectively). Higher erythrocyte sedimentation rate (ESR; ≥ 20) was associated with higher TRAIL expression and CD20 cell infiltration in contrast to lower ESR (<20; p <0.05). ICAM-1, TRAIL, and MMP-3 were expressed more predominantly in anti-SSA-positive than in anti-SSA-negative patients with SS. There was a significant difference in CD20 cell infiltration and MMP-3 expression between primary SS and secondary SS. Biopsy of a grade IV showed a significantly increased expression of TRAIL (44.9 ± 4.5 vs 40.8 ± 3.6, p = 0.013) and MMP-3 (62.7 ± 6.3 vs 54.4 ± 7.3, p = 0.003) in mononuclear cells as compared to those of grade III. Conclusion. In our study, pathologic grading with a higher grade (grade IV) and the presence of SSA or a higher titer of ANA were significantly associated with the overexpression of TRAIL, MMP-3, or ICAM-1 in the salivary gland mononuclear cells in patients with SS. The Journal of Rheumatology",
keywords = "Antinuclear antibody, Matrix metalloproteinases, Minor salivary gland biopsy, Sj{\"o}gren's Syndrome, Trail",
author = "Chen, {Wei Sheng} and Lin, {Kuan Chia} and Chen, {Chun Hsiung} and Hsien-Tzung Liao and Wang, {Hon Pin} and Li, {Wing Y.} and Lee, {Hui Ting} and Tsai, {Chang Youh} and Chou, {Chung Tei}",
year = "2009",
month = "5",
doi = "10.3899/jrheum.080733",
language = "English",
volume = "36",
pages = "989--996",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
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TY - JOUR

T1 - Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjögren's Syndrome

AU - Chen, Wei Sheng

AU - Lin, Kuan Chia

AU - Chen, Chun Hsiung

AU - Liao, Hsien-Tzung

AU - Wang, Hon Pin

AU - Li, Wing Y.

AU - Lee, Hui Ting

AU - Tsai, Chang Youh

AU - Chou, Chung Tei

PY - 2009/5

Y1 - 2009/5

N2 - Objective. Sjögren's syndrome (SS) is an inflammatory autoimmune disease.We investigated important factors associated with the expression of inflammation-related molecules in minor salivary gland (MSG) mononuclear cells in patients with SS. Methods. Thirty-four patients with SS with a MSG biopsy grading of either grade III (10 patients) or grade IV (24 patients) were enrolled. The age, sex, autoantibodies, cell infiltration, and intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-3 (MMP-3), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), or CXCR3 expression were also analyzed. Results. Ten of the 34 patients with SS were diagnosed with secondary SS; in these patients, the diagnosis of rheumatoid arthritis was confirmed in 8 and systemic lupus erythematosus in 2. TRAIL and ICAM-1 were overexpressed in patients with antinuclear antibodies (ANA) > 1:160, compared to those with titer <1:160 (45.1 ± 4.4 vs 41.2 ± 3.9, p = 0.021, and 15.2 ± 5.7 vs 10.8 ± 3.3, p = 0.018, respectively). Higher erythrocyte sedimentation rate (ESR; ≥ 20) was associated with higher TRAIL expression and CD20 cell infiltration in contrast to lower ESR (<20; p <0.05). ICAM-1, TRAIL, and MMP-3 were expressed more predominantly in anti-SSA-positive than in anti-SSA-negative patients with SS. There was a significant difference in CD20 cell infiltration and MMP-3 expression between primary SS and secondary SS. Biopsy of a grade IV showed a significantly increased expression of TRAIL (44.9 ± 4.5 vs 40.8 ± 3.6, p = 0.013) and MMP-3 (62.7 ± 6.3 vs 54.4 ± 7.3, p = 0.003) in mononuclear cells as compared to those of grade III. Conclusion. In our study, pathologic grading with a higher grade (grade IV) and the presence of SSA or a higher titer of ANA were significantly associated with the overexpression of TRAIL, MMP-3, or ICAM-1 in the salivary gland mononuclear cells in patients with SS. The Journal of Rheumatology

AB - Objective. Sjögren's syndrome (SS) is an inflammatory autoimmune disease.We investigated important factors associated with the expression of inflammation-related molecules in minor salivary gland (MSG) mononuclear cells in patients with SS. Methods. Thirty-four patients with SS with a MSG biopsy grading of either grade III (10 patients) or grade IV (24 patients) were enrolled. The age, sex, autoantibodies, cell infiltration, and intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-3 (MMP-3), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), or CXCR3 expression were also analyzed. Results. Ten of the 34 patients with SS were diagnosed with secondary SS; in these patients, the diagnosis of rheumatoid arthritis was confirmed in 8 and systemic lupus erythematosus in 2. TRAIL and ICAM-1 were overexpressed in patients with antinuclear antibodies (ANA) > 1:160, compared to those with titer <1:160 (45.1 ± 4.4 vs 41.2 ± 3.9, p = 0.021, and 15.2 ± 5.7 vs 10.8 ± 3.3, p = 0.018, respectively). Higher erythrocyte sedimentation rate (ESR; ≥ 20) was associated with higher TRAIL expression and CD20 cell infiltration in contrast to lower ESR (<20; p <0.05). ICAM-1, TRAIL, and MMP-3 were expressed more predominantly in anti-SSA-positive than in anti-SSA-negative patients with SS. There was a significant difference in CD20 cell infiltration and MMP-3 expression between primary SS and secondary SS. Biopsy of a grade IV showed a significantly increased expression of TRAIL (44.9 ± 4.5 vs 40.8 ± 3.6, p = 0.013) and MMP-3 (62.7 ± 6.3 vs 54.4 ± 7.3, p = 0.003) in mononuclear cells as compared to those of grade III. Conclusion. In our study, pathologic grading with a higher grade (grade IV) and the presence of SSA or a higher titer of ANA were significantly associated with the overexpression of TRAIL, MMP-3, or ICAM-1 in the salivary gland mononuclear cells in patients with SS. The Journal of Rheumatology

KW - Antinuclear antibody

KW - Matrix metalloproteinases

KW - Minor salivary gland biopsy

KW - Sjögren's Syndrome

KW - Trail

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