Auto-synthesis of fluoro-18-FDDNP on Alzheimer's research

Kang Wei Chang, Shih Ying Lee, Wuu Jyh Lin, Chia Chieh Chen, Jenn Tzong Chen, Hsin Ell Wang

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Alzheimer's disease (AD) is an epidemic neurodegenerative disorder-affecting millions of elderly adults. Senile plaques (SPs) and neurofibrillay tangles (NFTs) are hallmarks in AD. [18F]FDDNP (2-(1-{ 6-[(2-fluoroethyl)(methyl)amino]-2-naphthyl} ethylidene)malononitrile) was superior binding with SPs and NFTs. High quality [18F]FDDNP was produced by an auto synthesizer. [18F]FDDNP has a partition coefficient of 1.93±0.10 mean was it shows hydrophobic ability to penetrate the blood brain barrier (BBB). In vitro autoradiography saturated with Tg2576, showed high retention ratio for Aβ rich regions (for example in Tg2576, hippocampus and frontal cortex were 2.10±0.34 and 1.90±0.17, respectively) and human brain section, postcentral gyrus, and occipital lobe showed significant different retention ratio (1.48±0.04 and 2.3±70.13, respectively). In ex vivo study, in hippocampus and frontal cortex region, Tg2576 had better retention than control mice. (2.40±0.33 and 2.19±0.22, respectively). In this paper, we show our modified protocol for the synthesis of [18F]FDDNP and report in vitro, in vivo and ex vivo results in transgenic mice as a model for applications in Aβ radiopharmaceutical research.
原文英語
頁(從 - 到)414-417
頁數4
期刊Journal of Labelled Compounds and Radiopharmaceuticals
53
發行號5-6
DOIs
出版狀態已發佈 - 5月 1 2010
對外發佈

ASJC Scopus subject areas

  • 分析化學
  • 生物化學
  • 放射學、核子醫學和影像學
  • 藥物發現
  • 光譜
  • 有機化學

指紋

深入研究「Auto-synthesis of fluoro-18-FDDNP on Alzheimer's research」主題。共同形成了獨特的指紋。

引用此