Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

Nobuhiro Nakai, Susumu Otsuka, Jihwan Myung, Toru Takumi

研究成果: 雜誌貢獻回顧型文獻

7 引文 斯高帕斯(Scopus)

摘要

Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.
原文英語
頁(從 - 到)976-984
頁數9
期刊Science China Life Sciences
58
發行號10
DOIs
出版狀態已發佈 - 十月 1 2015
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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