Atypical renal clearance of nanoparticles larger than the kidney filtration threshold

Christophorus F. Adhipandito, Siu Hung Cheung, Yu Han Lin, Si Han Wu

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

In recent years, several publications reported that nanoparticles larger than the kidney filtration threshold were found intact in the urine after being injected into laboratory mice. This theoretically should not be possible, as it is widely known that the kidneys prevent molecules larger than 6–8 nm from escaping into the urine. This is interesting because it implies that some nanoparticles can overcome the size limit for renal clearance. What kinds of nanoparticles can “bypass” the glomerular filtration barrier and cross into the urine? What physical and chemical characteristics are essential for nanoparticles to have this ability? And what are the biomolecular and cellular mechanisms that are involved? This review attempts to answer those questions and summarize known reports of renal-clearable large nanoparticles.

原文英語
文章編號11182
期刊International journal of molecular sciences
22
發行號20
DOIs
出版狀態已發佈 - 十月 1 2021

ASJC Scopus subject areas

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學

指紋

深入研究「Atypical renal clearance of nanoparticles larger than the kidney filtration threshold」主題。共同形成了獨特的指紋。

引用此