Attenuated cardiac mitochondrial-dependent apoptotic effects by Li-Fu formula in hamsters fed with a hypercholesterol diet

Bor Show Tzang, Wei Wen Kuo, Tsai Ching Hsu, Mei Haung Chain, Chao Hung Lai, Wen Hong Wang, Fuu Jen Tsai, Chang Hai Tsai, Chieh His Wu, Chih Yang Huang

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Apoptosis involves in the pathogenesis of various cardiac abnormalities. This study intends to evaluate the effects of Li-Fu formula on cardiac apoptosis induced by hyper-cholesterol diet. Twenty-four male Golden Syrian hamsters were randomly divided into Control, Cholesterol and Li-Fu formula groups. Histopathological analysis, western blotting and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed to measure the effects of Li-Fu formula on left ventricle. Significantly reduced TUNEL-positive cells and mitochondria- dependent apoptosis were observed in the left ventricle of hamsters from Li-Fu formula group compared to the Cholesterol group. Additionally, induced cardiac insulin like growth factor I receptor (IGFIR)-dependent survival pathway was detected in the Li-Fu formula group compared to the Cholesterol group. Besides, minor fibrosis, increased collagen deposition, and myofibril disarray was detected in the Cholesterol group, whereas the reductions of collagen deposition and myofibril disarray were observed in the Li-Fu formula group. This study demonstrated that Li-Fu formula not only reduced the mitochondria-dependent apoptosis and fibrosis, but also enhanced the IGF-I survival pathway in the left ventricle from high cholesterol-fed hamsters. We suggest the protective effects of Li-Fu formula on cardiac apoptosis and therapeutic potentials against cardiovascular disease.

原文英語
文章編號530345
期刊Evidence-based Complementary and Alternative Medicine
2011
DOIs
出版狀態已發佈 - 2011
對外發佈

ASJC Scopus subject areas

  • 補充和替代醫學

指紋

深入研究「Attenuated cardiac mitochondrial-dependent apoptotic effects by Li-Fu formula in hamsters fed with a hypercholesterol diet」主題。共同形成了獨特的指紋。

引用此