Attention deficit/hyperactivity disorder and urinary nonylphenol levels: A case-control study in taiwanese children

Ching Jung Yu, Jung Chieh Du, Hsien Chih Chiou, Shang Han Yang, Kai Wei Liao, Winnie Yang, Ming Yi Chung, Ling Chu Chien, Betau Hwang, Mei Lien Chen

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

Objective: Nonylphenol (NP) belongs to the family of endocrine disruptors, and it is widely used in industrial applications and is ubiquitous in daily foods. Animal studies have suggested that NP exposure might promote motor hyperactivity, likely by causing deficits in dopaminergic neurons. However, research assessing NP exposure and epidemiology studies on human populations are limited. The aim of this study was to explore the association between child NP exposure and ADHD while considering particular covariants, such as lead levels and dopamine-related gene variations. Methods: A case-control study was conducted on patients with clinically diagnosed ADHD; the Swan son, Nolan and Pelham, Fourth Revision (SNAP-IV) questionnaire was used to identify normal controls aged 4-15 years. Participants were examined for urinary NP concentrations, blood lead levels, and select single-nucleotide polymorphisms of two dopamine-related genes (D4 dopamine receptor, DRD4, and dopamine transporter, DAT1). Socio-demo-graphic variables, maternal lifestyle factors during pregnancy and family medical history were obtained using a questionnaire. Results: A total of 97 children with doctor-diagnosed ADHD and 110 normal controls were enrolled. The blood lead levels in both groups were similar (1.57±0.73 vs. 1.73±0.77 pg/dL, p = 0.15). No significant difference in urinary NP concentration was found between the children with ADHD and the control subjects (4.52±3.22 pg/g cr. vs. 4.64±2.95 pg/g cr., p = 0.43). ADHD was significantly more prevalent among males in this study (male to female ratio: 5:1 for the ADHD group and 1.3:1 for the control group, p
原文英語
文章編號e0149558
期刊PLoS One
11
發行號2
DOIs
出版狀態已發佈 - 二月 1 2016

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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