Atorvastatin prevents atrial fibrillation in patients with bradyarrhythmias and implantation of an atrial-based or dual-chamber pacemaker: A prospective randomized trial

Chia Ti Tsai, Ling Ping Lai, Juey Jen Hwang, Yi Chih Wang, Fu Tien Chiang, Jiunn Lee Lin

研究成果: 雜誌貢獻文章同行評審

32 引文 斯高帕斯(Scopus)

摘要

Background: Increasing evidence suggests that atrial fibrillation (AF) is an inflammatory disease. Statins is an anti-inflammatory agent. The present study was conducted to test the efficacy of atorvastatin in preventing paroxysmal AF or atrial high rate episodes (AHEs) in patients with bradyarrhythmias and implantation of an atrial-based or dual-chamber pacemaker. Methods: The effect of atorvastatin on time to the first attack of AF or AHE (≥180 per minute and ≥1 or 10 minutes), which was accurately detected by pacemaker interrogation, was evaluated in an open-label prospective randomized design for 1 year of follow-up. Results: Fifty-two patients (23 males, 70 ± 13 years old) were randomized to the statin group (atorvastatin 20 mg/d) and 54 (25 males, 72 ± 13 years old) to the nonstatin group. Event-free survivals from AHE ≥1 minute were not significantly different between the 2 groups (log-rank P = .410). However, patients in the nonstatin group were more likely to develop AHE ≥10 minutes than those in the statin group (log-rank P = .028). Atrial high rate episode ≥10 minutes occurred in 3 (5.8%) of 51 patients in the statin group after 1 year of follow-up, and 10 (19.2%) of 52 patients (odds ratio 0.26, P = .041) in the nonstatin group. The mean left atrial volume of the statin group was significantly lower than that of the nonstatin group at the end of follow-up (39.7 ± 1.7 vs 43.7 ± 1.9 mL, P < .0001). Conclusions: The present study demonstrated the efficacy of atorvastatin in preventing significant AF (≥10 minutes) and left atrial enlargement in patients with bradyarrhythmias and implantation of a pacemaker.
原文英語
頁(從 - 到)65-70
頁數6
期刊American Heart Journal
156
發行號1
DOIs
出版狀態已發佈 - 7月 1 2008
對外發佈

Keywords

  • atorvastatin
  • Atrial Fibrillation
  • Bradycardia
  • artificial heart pacemaker

ASJC Scopus subject areas

  • 心臟病學與心血管醫學

指紋

深入研究「Atorvastatin prevents atrial fibrillation in patients with bradyarrhythmias and implantation of an atrial-based or dual-chamber pacemaker: A prospective randomized trial」主題。共同形成了獨特的指紋。

引用此