Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation

Shun Tai Yang, Jia Wei Lin, Bi Ying Chiu, Yao Chin Hsu, Ching Ping Chang, Cheng Kuei Chang

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

Astragaloside (AST) is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. We directly tested the therapeutic effects of AST in a rat model of traumatic brain injury (TBI). One hour after the onset of TBI rats were given Saline (1 ml/kg) or AST (20-80 mg/kg) via i.p. injection. AST causes the attenuation of TBI-induced cerebral contusion, neuronal apoptosis, and neurological motor dysfunction. TBI-induced microglial activation evidenced by the morphological transformation of microglia (or ameboid microglia) and the microglial overexpression of tumor necrosis factor-alpha was reduced by AST. Our results indicate that AST may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats.
原文英語
頁(從 - 到)1357-1370
頁數14
期刊American Journal of Chinese Medicine
42
發行號6
DOIs
出版狀態已發佈 - 五月 16 2014

指紋

Microglia
Apoptosis
Cerebrovascular Disorders
Therapeutic Uses
Tumor Necrosis Factor-alpha
Traumatic Brain Injury
Injections
Brain Contusion

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Medicine(all)

引用此文

Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation. / Yang, Shun Tai; Lin, Jia Wei; Chiu, Bi Ying; Hsu, Yao Chin; Chang, Ching Ping; Chang, Cheng Kuei.

於: American Journal of Chinese Medicine, 卷 42, 編號 6, 16.05.2014, p. 1357-1370.

研究成果: 雜誌貢獻文章

@article{1ea9a800db3e429ca40697ee7e8ee40a,
title = "Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation",
abstract = "Astragaloside (AST) is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. We directly tested the therapeutic effects of AST in a rat model of traumatic brain injury (TBI). One hour after the onset of TBI rats were given Saline (1 ml/kg) or AST (20-80 mg/kg) via i.p. injection. AST causes the attenuation of TBI-induced cerebral contusion, neuronal apoptosis, and neurological motor dysfunction. TBI-induced microglial activation evidenced by the morphological transformation of microglia (or ameboid microglia) and the microglial overexpression of tumor necrosis factor-alpha was reduced by AST. Our results indicate that AST may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats.",
keywords = "Astragaloside, Microglia, Traumatic Brain Injury, Tumor Necrosis Factor-Alpha",
author = "Yang, {Shun Tai} and Lin, {Jia Wei} and Chiu, {Bi Ying} and Hsu, {Yao Chin} and Chang, {Ching Ping} and Chang, {Cheng Kuei}",
year = "2014",
month = "5",
day = "16",
doi = "10.1142/S0192415X14500852",
language = "English",
volume = "42",
pages = "1357--1370",
journal = "American Journal of Chinese Medicine",
issn = "0192-415X",
publisher = "World Scientific Publishing Co. Pte Ltd",
number = "6",

}

TY - JOUR

T1 - Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation

AU - Yang, Shun Tai

AU - Lin, Jia Wei

AU - Chiu, Bi Ying

AU - Hsu, Yao Chin

AU - Chang, Ching Ping

AU - Chang, Cheng Kuei

PY - 2014/5/16

Y1 - 2014/5/16

N2 - Astragaloside (AST) is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. We directly tested the therapeutic effects of AST in a rat model of traumatic brain injury (TBI). One hour after the onset of TBI rats were given Saline (1 ml/kg) or AST (20-80 mg/kg) via i.p. injection. AST causes the attenuation of TBI-induced cerebral contusion, neuronal apoptosis, and neurological motor dysfunction. TBI-induced microglial activation evidenced by the morphological transformation of microglia (or ameboid microglia) and the microglial overexpression of tumor necrosis factor-alpha was reduced by AST. Our results indicate that AST may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats.

AB - Astragaloside (AST) is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. We directly tested the therapeutic effects of AST in a rat model of traumatic brain injury (TBI). One hour after the onset of TBI rats were given Saline (1 ml/kg) or AST (20-80 mg/kg) via i.p. injection. AST causes the attenuation of TBI-induced cerebral contusion, neuronal apoptosis, and neurological motor dysfunction. TBI-induced microglial activation evidenced by the morphological transformation of microglia (or ameboid microglia) and the microglial overexpression of tumor necrosis factor-alpha was reduced by AST. Our results indicate that AST may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats.

KW - Astragaloside

KW - Microglia

KW - Traumatic Brain Injury

KW - Tumor Necrosis Factor-Alpha

UR - http://www.scopus.com/inward/record.url?scp=84929298712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929298712&partnerID=8YFLogxK

U2 - 10.1142/S0192415X14500852

DO - 10.1142/S0192415X14500852

M3 - Article

VL - 42

SP - 1357

EP - 1370

JO - American Journal of Chinese Medicine

JF - American Journal of Chinese Medicine

SN - 0192-415X

IS - 6

ER -