Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation

Shun Tai Yang, Jia Wei Lin, Bi Ying Chiu, Yao Chin Hsu, Ching Ping Chang, Cheng Kuei Chang

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Astragaloside (AST) is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. We directly tested the therapeutic effects of AST in a rat model of traumatic brain injury (TBI). One hour after the onset of TBI rats were given Saline (1 ml/kg) or AST (20-80 mg/kg) via i.p. injection. AST causes the attenuation of TBI-induced cerebral contusion, neuronal apoptosis, and neurological motor dysfunction. TBI-induced microglial activation evidenced by the morphological transformation of microglia (or ameboid microglia) and the microglial overexpression of tumor necrosis factor-alpha was reduced by AST. Our results indicate that AST may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats.
原文英語
頁(從 - 到)1357-1370
頁數14
期刊American Journal of Chinese Medicine
42
發行號6
DOIs
出版狀態已發佈 - 五月 16 2014

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Medicine(all)

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