Asthma and early smoking associated with high risk of panic disorder in adolescents and young adults

Meng Huan Wu, Wei Er Wang, Tsu Nai Wang, Ni Chi Lin, Mong Liang Lu, Leanna M.W. Lui, Roger S. McIntyre, Vincent Chin Hung Chen

研究成果: 雜誌貢獻文章同行評審

摘要

Purpose: Studies have reported a strong link between asthma and panic disorder. We conducted a 17-year community-based large cohort study to examine the relationship between asthma, early smoking initiation, and panic disorder during adolescence and early adulthood. Methods: A total of 162,766 participants aged 11–16 years were categorized into asthma and nonasthma groups at baseline and compared within the observation period. Covariates during late childhood or adolescence included parental education, cigarette smoking by family members of participants, and participant’s gender, age, alcohol consumption, smoking, and exercise habits. Data for urbanicity, prednisone use, allergic comorbidity, and Charlson comorbidity index were acquired from the National Health Insurance Research Database. The Cox proportional-hazards model was used to evaluate the association between asthma and panic disorder. Results: Our findings revealed that asthma increased the risk of panic disorder after adjustment for key confounders in the Cox proportional hazard regression model (adjusted HR: 1.70, 95% CI 1.28–2.26). Hospitalizations or visits to the emergency department for asthma exhibited a dose–response effect on the panic disorder (adjusted HR: 2.07, 95% CI 1.30–3.29). Patients with asthma with onset before 20 years of age who smoked during late childhood or adolescence had the greatest risk for panic disorder (adjusted HR: 4.95, 95% CI 1.23–19.90). Conclusions: Patients newly diagnosed with asthma had a 1.7-times higher risk of developing panic disorder. Smoking during late childhood or adolescence increased the risk for developing the panic disorder in patients with asthma.
原文英語
頁(從 - 到)583-594
頁數12
期刊Social Psychiatry and Psychiatric Epidemiology
57
發行號3
DOIs
出版狀態已發佈 - 3月 2022

ASJC Scopus subject areas

  • 流行病學
  • 社會心理學
  • 健康(社會科學)
  • 精神病學和心理健康

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