Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma

Hui Chun Tai, Hsuan Ying Huang, Sung Wei Lee, Ching Yih Lin, Ming Jen Sheu, Shih Lun Chang, Li Ching Wu, Yow Ling Shiue, Wen Ren Wu, Chun Mao Lin, Chien Feng Li

研究成果: 雜誌貢獻文章

24 引文 斯高帕斯(Scopus)

摘要

Aims: Deregulated chromatin remodelling often leads to aberrant gene expression in cells, thereby implicating tumour development and progression. As a subunit of remodelling and spacing factor complex, Rsf-1 (HBXAP), a novel nuclear protein with histone chaperon function, mediates ATPase-dependent chromatin remodelling and confers tumour aggressiveness in common carcinomas. However, the expression of Rsf-1 has never been reported in nasopharyngeal carcinoma (NPC). This study aimed at evaluating the expression status, associations with clincopathological variables and prognostic implications of Rsf-1 in a well-defined cohort of NPC. Methods: Rsf-1 immunoexpression was retrospectively assessed in biopsies of 108 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The results were correlated with the clinicopathological features, therapeutic response, local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS) and disease-specific survival (DSS). Results: Present in 49 cases (45%), Rsf-1 overexpression was associated with N2,3 status (p=0.016), American Joint Committee on Cancer stage 3, 4 (p=0.004), and incomplete therapeutic response (p=0.041). In multivariate analyses, Rsf-1 overexpression not only emerged as the sole independent adverse prognosticator for LRFS (p=0.0002, RR 5.287) but also independently predicted worse DMFS (p=0.0011, RR 3.185) and DSS (p3,4 (p=0.0454) and N 2,3 (p=0.0319), respectively. Conclusion: Rsf-1 overexpression is common and is associated with adverse prognosticators and therapeutic response, which confers tumour aggressiveness through chromatin remodelling, and represents a potential prognostic biomarker in NPC.

原文英語
頁(從 - 到)248-253
頁數6
期刊Journal of Clinical Pathology
65
發行號3
DOIs
出版狀態已發佈 - 三月 2012

    指紋

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

引用此

Tai, H. C., Huang, H. Y., Lee, S. W., Lin, C. Y., Sheu, M. J., Chang, S. L., Wu, L. C., Shiue, Y. L., Wu, W. R., Lin, C. M., & Li, C. F. (2012). Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma. Journal of Clinical Pathology, 65(3), 248-253. https://doi.org/10.1136/jclinpath-2011-200413