Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

Chih Chin Kao, Shih Ying Cheng, Mei Yi Wu, Shu Chen Chien, Hsing Fang Lu, Yu Wen Hsu, Yan Feng Zhang, Mai Szu Wu, Wei Chiao Chang

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62% (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.

原文英語
文章編號291
期刊BMC Nephrology
18
發行號1
DOIs
出版狀態已發佈 - 九月 7 2017

指紋

Endothelins
Renal Insufficiency
Chronic Kidney Failure
Genes
Tibial Arteries
Quantitative Trait Loci
Vasoconstrictor Agents
Single Nucleotide Polymorphism
Blood Vessels
Cause of Death
Hospitalization
Homeostasis
Biomarkers
Gene Expression

ASJC Scopus subject areas

  • Nephrology

引用此文

Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure. / Kao, Chih Chin; Cheng, Shih Ying; Wu, Mei Yi; Chien, Shu Chen; Lu, Hsing Fang; Hsu, Yu Wen; Zhang, Yan Feng; Wu, Mai Szu; Chang, Wei Chiao.

於: BMC Nephrology, 卷 18, 編號 1, 291, 07.09.2017.

研究成果: 雜誌貢獻文章

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abstract = "Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62{\%} (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.",
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AU - Kao, Chih Chin

AU - Cheng, Shih Ying

AU - Wu, Mei Yi

AU - Chien, Shu Chen

AU - Lu, Hsing Fang

AU - Hsu, Yu Wen

AU - Zhang, Yan Feng

AU - Wu, Mai Szu

AU - Chang, Wei Chiao

PY - 2017/9/7

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N2 - Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62% (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.

AB - Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62% (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.

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