Associations between urinary total arsenic levels, fetal development, and neonatal birth outcomes: A cohort study in Taiwan

Kai Wei Liao, Chia Huang Chang, Ming Song Tsai, Ling Chu Chien, Ming Yi Chung, I. Fang Mao, Yen An Tsai, Mei Lien Chen

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

Background Arsenic exposure is a global health concern. Several studies have focused on chronic arsenic exposure in adults; however, limited data are available regarding the potential adverse effects of prenatal exposure on fetuses and neonates. Objectives To assess which time point maternal arsenic exposure may influence the fetus during pregnancy and birth outcomes. Methods In this study, total arsenic concentrations were analyzed in urine samples collected from 130 women with singleton pregnancies (22–45 years old) in Taiwan from March to December of 2010. All fetal biometric measurements in each trimester period and birth outcomes at delivery were obtained. We applied a generalized estimating equation model and multivariate regression models to evaluate the associations between maternal urinary total arsenic (UtAs) exposure during pregnancy, fetal biometric measurements, and neonatal birth outcomes. Results We observed statistically significant correlations between maternal UtAs levels and the fetal biparietal diameter over all three trimesters (β = − 1.046 mm, p < 0.05). Multiple regression analyses showed a negative association between maternal UtAs levels and chest circumference in the first trimester (β = − 0.721 cm, p < 0.05), and second-trimester UtAs exposure was associated with decreases in birth weight (β = − 173.26 g, p < 0.01), head circumference (β = − 0.611 cm, p < 0.05), and chest circumference (β = − 0.654 cm, p < 0.05). Dose-response relationships were also observed for maternal UtAs exposure and birth outcomes. Conclusions We identified a negative relationship between maternal UtAs levels during pregnancy, fetal development, and neonatal birth outcomes. These findings should be confirmed in future studies with large sample sizes.
原文英語
頁(從 - 到)1373-1379
頁數7
期刊Science of the Total Environment
612
DOIs
出版狀態已發佈 - 一月 15 2018

指紋

development level
Arsenic
arsenic
pregnancy
biometry
Biometrics
dose-response relationship
neonate
exposure
urine
multiple regression
Health

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

引用此文

Associations between urinary total arsenic levels, fetal development, and neonatal birth outcomes : A cohort study in Taiwan. / Liao, Kai Wei; Chang, Chia Huang; Tsai, Ming Song; Chien, Ling Chu; Chung, Ming Yi; Mao, I. Fang; Tsai, Yen An; Chen, Mei Lien.

於: Science of the Total Environment, 卷 612, 15.01.2018, p. 1373-1379.

研究成果: 雜誌貢獻文章

Liao, Kai Wei ; Chang, Chia Huang ; Tsai, Ming Song ; Chien, Ling Chu ; Chung, Ming Yi ; Mao, I. Fang ; Tsai, Yen An ; Chen, Mei Lien. / Associations between urinary total arsenic levels, fetal development, and neonatal birth outcomes : A cohort study in Taiwan. 於: Science of the Total Environment. 2018 ; 卷 612. 頁 1373-1379.
@article{5d7e250421574026aa7f0c2ca59e4b63,
title = "Associations between urinary total arsenic levels, fetal development, and neonatal birth outcomes: A cohort study in Taiwan",
abstract = "Background Arsenic exposure is a global health concern. Several studies have focused on chronic arsenic exposure in adults; however, limited data are available regarding the potential adverse effects of prenatal exposure on fetuses and neonates. Objectives To assess which time point maternal arsenic exposure may influence the fetus during pregnancy and birth outcomes. Methods In this study, total arsenic concentrations were analyzed in urine samples collected from 130 women with singleton pregnancies (22–45 years old) in Taiwan from March to December of 2010. All fetal biometric measurements in each trimester period and birth outcomes at delivery were obtained. We applied a generalized estimating equation model and multivariate regression models to evaluate the associations between maternal urinary total arsenic (UtAs) exposure during pregnancy, fetal biometric measurements, and neonatal birth outcomes. Results We observed statistically significant correlations between maternal UtAs levels and the fetal biparietal diameter over all three trimesters (β = − 1.046 mm, p < 0.05). Multiple regression analyses showed a negative association between maternal UtAs levels and chest circumference in the first trimester (β = − 0.721 cm, p < 0.05), and second-trimester UtAs exposure was associated with decreases in birth weight (β = − 173.26 g, p < 0.01), head circumference (β = − 0.611 cm, p < 0.05), and chest circumference (β = − 0.654 cm, p < 0.05). Dose-response relationships were also observed for maternal UtAs exposure and birth outcomes. Conclusions We identified a negative relationship between maternal UtAs levels during pregnancy, fetal development, and neonatal birth outcomes. These findings should be confirmed in future studies with large sample sizes.",
keywords = "Birth outcomes, Cohort study, Fetal development, Maternal exposure, Urinary total arsenic",
author = "Liao, {Kai Wei} and Chang, {Chia Huang} and Tsai, {Ming Song} and Chien, {Ling Chu} and Chung, {Ming Yi} and Mao, {I. Fang} and Tsai, {Yen An} and Chen, {Mei Lien}",
year = "2018",
month = "1",
day = "15",
doi = "10.1016/j.scitotenv.2017.08.312",
language = "English",
volume = "612",
pages = "1373--1379",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

TY - JOUR

T1 - Associations between urinary total arsenic levels, fetal development, and neonatal birth outcomes

T2 - A cohort study in Taiwan

AU - Liao, Kai Wei

AU - Chang, Chia Huang

AU - Tsai, Ming Song

AU - Chien, Ling Chu

AU - Chung, Ming Yi

AU - Mao, I. Fang

AU - Tsai, Yen An

AU - Chen, Mei Lien

PY - 2018/1/15

Y1 - 2018/1/15

N2 - Background Arsenic exposure is a global health concern. Several studies have focused on chronic arsenic exposure in adults; however, limited data are available regarding the potential adverse effects of prenatal exposure on fetuses and neonates. Objectives To assess which time point maternal arsenic exposure may influence the fetus during pregnancy and birth outcomes. Methods In this study, total arsenic concentrations were analyzed in urine samples collected from 130 women with singleton pregnancies (22–45 years old) in Taiwan from March to December of 2010. All fetal biometric measurements in each trimester period and birth outcomes at delivery were obtained. We applied a generalized estimating equation model and multivariate regression models to evaluate the associations between maternal urinary total arsenic (UtAs) exposure during pregnancy, fetal biometric measurements, and neonatal birth outcomes. Results We observed statistically significant correlations between maternal UtAs levels and the fetal biparietal diameter over all three trimesters (β = − 1.046 mm, p < 0.05). Multiple regression analyses showed a negative association between maternal UtAs levels and chest circumference in the first trimester (β = − 0.721 cm, p < 0.05), and second-trimester UtAs exposure was associated with decreases in birth weight (β = − 173.26 g, p < 0.01), head circumference (β = − 0.611 cm, p < 0.05), and chest circumference (β = − 0.654 cm, p < 0.05). Dose-response relationships were also observed for maternal UtAs exposure and birth outcomes. Conclusions We identified a negative relationship between maternal UtAs levels during pregnancy, fetal development, and neonatal birth outcomes. These findings should be confirmed in future studies with large sample sizes.

AB - Background Arsenic exposure is a global health concern. Several studies have focused on chronic arsenic exposure in adults; however, limited data are available regarding the potential adverse effects of prenatal exposure on fetuses and neonates. Objectives To assess which time point maternal arsenic exposure may influence the fetus during pregnancy and birth outcomes. Methods In this study, total arsenic concentrations were analyzed in urine samples collected from 130 women with singleton pregnancies (22–45 years old) in Taiwan from March to December of 2010. All fetal biometric measurements in each trimester period and birth outcomes at delivery were obtained. We applied a generalized estimating equation model and multivariate regression models to evaluate the associations between maternal urinary total arsenic (UtAs) exposure during pregnancy, fetal biometric measurements, and neonatal birth outcomes. Results We observed statistically significant correlations between maternal UtAs levels and the fetal biparietal diameter over all three trimesters (β = − 1.046 mm, p < 0.05). Multiple regression analyses showed a negative association between maternal UtAs levels and chest circumference in the first trimester (β = − 0.721 cm, p < 0.05), and second-trimester UtAs exposure was associated with decreases in birth weight (β = − 173.26 g, p < 0.01), head circumference (β = − 0.611 cm, p < 0.05), and chest circumference (β = − 0.654 cm, p < 0.05). Dose-response relationships were also observed for maternal UtAs exposure and birth outcomes. Conclusions We identified a negative relationship between maternal UtAs levels during pregnancy, fetal development, and neonatal birth outcomes. These findings should be confirmed in future studies with large sample sizes.

KW - Birth outcomes

KW - Cohort study

KW - Fetal development

KW - Maternal exposure

KW - Urinary total arsenic

UR - http://www.scopus.com/inward/record.url?scp=85028991995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028991995&partnerID=8YFLogxK

U2 - 10.1016/j.scitotenv.2017.08.312

DO - 10.1016/j.scitotenv.2017.08.312

M3 - Article

AN - SCOPUS:85028991995

VL - 612

SP - 1373

EP - 1379

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -