摘要
Objective: We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients. Methods: Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0. ±. 9.7 and 64.3. ±. 12.3. years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques. Results: The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR. = 1.965, 95% CI. = 1.223-3.159, p. = 0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR. = 2.525, 95% CI. = 1.103-5.780, p. = 0.026). Conclusions: Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 1664-1667 |
| 頁數 | 4 |
| 期刊 | Clinical Biochemistry |
| 卷 | 46 |
| 發行號 | 16-17 |
| DOIs | |
| 出版狀態 | 已發佈 - 十一月 2013 |
指紋
ASJC Scopus subject areas
- Clinical Biochemistry
引用此文
Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population. / Chen, Chi Ching; Chen, Chien Chung; Tu, Jun Da; Wu, Yi Ling; Leu, Sy Jye.
於: Clinical Biochemistry, 卷 46, 編號 16-17, 11.2013, p. 1664-1667.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population
AU - Chen, Chi Ching
AU - Chen, Chien Chung
AU - Tu, Jun Da
AU - Wu, Yi Ling
AU - Leu, Sy Jye
PY - 2013/11
Y1 - 2013/11
N2 - Objective: We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients. Methods: Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0. ±. 9.7 and 64.3. ±. 12.3. years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques. Results: The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR. = 1.965, 95% CI. = 1.223-3.159, p. = 0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR. = 2.525, 95% CI. = 1.103-5.780, p. = 0.026). Conclusions: Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.
AB - Objective: We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients. Methods: Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0. ±. 9.7 and 64.3. ±. 12.3. years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques. Results: The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR. = 1.965, 95% CI. = 1.223-3.159, p. = 0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR. = 2.525, 95% CI. = 1.103-5.780, p. = 0.026). Conclusions: Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.
KW - CAD
KW - Gene polymorphisms
KW - Paraoxonase
KW - PON1
KW - PON2
UR - http://www.scopus.com/inward/record.url?scp=84886395571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886395571&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2013.05.066
DO - 10.1016/j.clinbiochem.2013.05.066
M3 - Article
C2 - 23742759
AN - SCOPUS:84886395571
VL - 46
SP - 1664
EP - 1667
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 16-17
ER -