Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population

Chi Ching Chen, Chien Chung Chen, Jun Da Tu, Yi Ling Wu, Sy Jye Leu

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Objective: We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients. Methods: Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0. ±. 9.7 and 64.3. ±. 12.3. years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques. Results: The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR. = 1.965, 95% CI. = 1.223-3.159, p. = 0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR. = 2.525, 95% CI. = 1.103-5.780, p. = 0.026). Conclusions: Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.

原文英語
頁(從 - 到)1664-1667
頁數4
期刊Clinical Biochemistry
46
發行號16-17
DOIs
出版狀態已發佈 - 十一月 2013

指紋

Aryldialkylphosphatase
Genetic Polymorphisms
Polymorphism
Coronary Artery Disease
Genes
Population
Alleles
Genotype
Polymerase chain reaction
Restriction Fragment Length Polymorphisms
Volunteers
Healthy Volunteers
Polymerase Chain Reaction
Control Groups

ASJC Scopus subject areas

  • Clinical Biochemistry

引用此文

Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population. / Chen, Chi Ching; Chen, Chien Chung; Tu, Jun Da; Wu, Yi Ling; Leu, Sy Jye.

於: Clinical Biochemistry, 卷 46, 編號 16-17, 11.2013, p. 1664-1667.

研究成果: 雜誌貢獻文章

Chen, Chi Ching ; Chen, Chien Chung ; Tu, Jun Da ; Wu, Yi Ling ; Leu, Sy Jye. / Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population. 於: Clinical Biochemistry. 2013 ; 卷 46, 編號 16-17. 頁 1664-1667.
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abstract = "Objective: We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients. Methods: Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0. ±. 9.7 and 64.3. ±. 12.3. years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques. Results: The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR. = 1.965, 95{\%} CI. = 1.223-3.159, p. = 0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR. = 2.525, 95{\%} CI. = 1.103-5.780, p. = 0.026). Conclusions: Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.",
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AU - Leu, Sy Jye

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N2 - Objective: We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients. Methods: Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0. ±. 9.7 and 64.3. ±. 12.3. years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques. Results: The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR. = 1.965, 95% CI. = 1.223-3.159, p. = 0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR. = 2.525, 95% CI. = 1.103-5.780, p. = 0.026). Conclusions: Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.

AB - Objective: We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients. Methods: Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0. ±. 9.7 and 64.3. ±. 12.3. years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques. Results: The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR. = 1.965, 95% CI. = 1.223-3.159, p. = 0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR. = 2.525, 95% CI. = 1.103-5.780, p. = 0.026). Conclusions: Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.

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