Associations between Genetic Polymorphisms of Epidermal Growth Factor Receptor (EGFR) and survival of colorectal cancer (crc) patients treated with 5-fluorouracil-based chemotherapy

Ching Yu Lai, Fung Chang Sung, Ling Ling Hsieh, Reiping Tang, Hung Yi Chiou, Fang Yang Wu, Chih Ching Yeh

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Purpose. This retrospective cohort study investigated the association between epidermal growth factor receptor (EGFR) polymorphisms and clinical outcomes in colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU)-based chemotherapy. Methods. We genotyped 3 EGFR polymorphisms including R497K, G-216T, and the (CA)n repeat, among 499 histologically confirmed CRC patients who had received 5-FU-based chemotherapy after surgery between 1995 and 2001. Survival analyses of EGFR polymorphisms were performed by the log rank test and Kaplan-Meier curves. We used the Cox proportional hazard model to evaluate the association between EGFR genotypes and clinical outcomes. Stratification analysis by gender, tumor stage, and subsite were also carried out. Results. CRC patients with the EGFR (CA)n L/L genotype compared to those with the S/S?S/L genotype had a significantly better overall survival (L, C20 repeats; S,\20 repeats) (hazard ratio (HR) 0.74; 95 % confidence interval (CI) 0.57-0.95), particularly for patients who were male (HR 0.63; 95 % CI 0.44-0.90), who had stage IV disease (HR 0.70; 95 % CI 0.49-0.99), and who had rectal cancer (HR 0.62; 95 % CI 0.42-0.92). Better survival was prominent among patients with the combined genotypes of EGFR (CA)n L/L, G-216T G/G, and R497K K/K (HR 0.51; 95 % CI 0.30-0.87), compared to those with the most common genotypes of the EGFR (CA)n S allele, G-216T G/G, and R497K R allele. Conclusions. EGFR polymorphisms can serve as prognostic predictors for CRC patients receiving 5-FU-based chemotherapy.
原文英語
頁(從 - 到)S599-S606
頁數8
期刊Annals of Surgical Oncology
20
發行號3 SUPPL.
DOIs
出版狀態已發佈 - 2013

Keywords

  • Colorectal Neoplasms
  • genetic polymorphism
  • survival rate

ASJC Scopus subject areas

  • Surgery
  • Oncology
  • Medicine(all)

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