Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis

Hsing Fang Lu, Kuo Sheng Hung, Yu Wen Hsu, Yu-Ting Tai, Lin Shan Huang, Yu Jia Wang, Henry Sung Ching Wong, Yi Hsiang Hsu, Wei Chiao Chang

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.
原文英語
文章編號e0140549
期刊PLoS One
10
發行號10
DOIs
出版狀態已發佈 - 十月 22 2015

指紋

osteoporosis
Polymorphism
Osteoporosis
Genes
Minerals
Bone
genetic polymorphism
Population
bone density
Bone Density
genes
pathogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

引用此文

Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis. / Lu, Hsing Fang; Hung, Kuo Sheng; Hsu, Yu Wen; Tai, Yu-Ting; Huang, Lin Shan; Wang, Yu Jia; Wong, Henry Sung Ching; Hsu, Yi Hsiang; Chang, Wei Chiao.

於: PLoS One, 卷 10, 編號 10, e0140549, 22.10.2015.

研究成果: 雜誌貢獻文章

Lu, Hsing Fang ; Hung, Kuo Sheng ; Hsu, Yu Wen ; Tai, Yu-Ting ; Huang, Lin Shan ; Wang, Yu Jia ; Wong, Henry Sung Ching ; Hsu, Yi Hsiang ; Chang, Wei Chiao. / Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis. 於: PLoS One. 2015 ; 卷 10, 編號 10.
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AU - Hung, Kuo Sheng

AU - Hsu, Yu Wen

AU - Tai, Yu-Ting

AU - Huang, Lin Shan

AU - Wang, Yu Jia

AU - Wong, Henry Sung Ching

AU - Hsu, Yi Hsiang

AU - Chang, Wei Chiao

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