Association of Sjögrens syndrome in patients with chronic hepatitis virus infection: A population-based analysis

Chih Ching Yeh, Wen Chang Wang, Chien Sheng Wu, Fung Chang Sung, Chien Tien Su, Ying Hua Shieh, Shih Ni Chang, Fu Hsiung Su

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Objective: The association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections. Materials and Methods: We identified 9,629 SS patients without other concomitant autoimmune diseases and 38,516 sex- and age-matched controls without SS from the Taiwan National Health Insurance claims data between 2000 and 2011. We utilized multivariate logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between SS and HBV and HCV infections. Sex- and age-specific (<55 and ≥55 years) risks of SS were evaluated. Results: The risk of SS was higher in patients with HCV than in those without chronic viral hepatitis (OR = 2.49, 95% CI = 2.16-2.86). Conversely, HBV infection was not associated with SS (OR = 1.10, 95% CI = 0.98-1.24). Younger HCV patients were at a higher risk for SS (<55 years: OR = 3.37, 95% CI = 2.62-4.35; ≥55 years: OR = 2.20, 95% CI = 1.84-2.62). Men with HCV were at a greater risk for SS (women: OR = 2.26, 95% CI = 1.94-2.63; men: OR = 4.22, 95% CI = 2.90-6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61, 95% CI = 1.21-2.14). Conclusion: HCV infection was associated with SS; however, HBV only associated with SS in men.
原文英語
文章編號e0161958
期刊PLoS One
11
發行號8
DOIs
出版狀態已發佈 - 八月 1 2016

指紋

chronic hepatitis
Hepatitis Viruses
Virus Diseases
Chronic Hepatitis
Hepatitis C virus
Viruses
odds ratio
confidence interval
viruses
Hepacivirus
infection
Odds Ratio
Population
Confidence Intervals
Taiwan
Health insurance
viral hepatitis
health insurance
gender
autoimmune diseases

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

引用此文

Association of Sjögrens syndrome in patients with chronic hepatitis virus infection : A population-based analysis. / Yeh, Chih Ching; Wang, Wen Chang; Wu, Chien Sheng; Sung, Fung Chang; Su, Chien Tien; Shieh, Ying Hua; Chang, Shih Ni; Su, Fu Hsiung.

於: PLoS One, 卷 11, 編號 8, e0161958, 01.08.2016.

研究成果: 雜誌貢獻文章

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title = "Association of Sj{\"o}grens syndrome in patients with chronic hepatitis virus infection: A population-based analysis",
abstract = "Objective: The association between Sj{\"o}gren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections. Materials and Methods: We identified 9,629 SS patients without other concomitant autoimmune diseases and 38,516 sex- and age-matched controls without SS from the Taiwan National Health Insurance claims data between 2000 and 2011. We utilized multivariate logistic regression to estimate the odds ratios (ORs) and 95{\%} confidence intervals (CIs) of the associations between SS and HBV and HCV infections. Sex- and age-specific (<55 and ≥55 years) risks of SS were evaluated. Results: The risk of SS was higher in patients with HCV than in those without chronic viral hepatitis (OR = 2.49, 95{\%} CI = 2.16-2.86). Conversely, HBV infection was not associated with SS (OR = 1.10, 95{\%} CI = 0.98-1.24). Younger HCV patients were at a higher risk for SS (<55 years: OR = 3.37, 95{\%} CI = 2.62-4.35; ≥55 years: OR = 2.20, 95{\%} CI = 1.84-2.62). Men with HCV were at a greater risk for SS (women: OR = 2.26, 95{\%} CI = 1.94-2.63; men: OR = 4.22, 95{\%} CI = 2.90-6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61, 95{\%} CI = 1.21-2.14). Conclusion: HCV infection was associated with SS; however, HBV only associated with SS in men.",
author = "Yeh, {Chih Ching} and Wang, {Wen Chang} and Wu, {Chien Sheng} and Sung, {Fung Chang} and Su, {Chien Tien} and Shieh, {Ying Hua} and Chang, {Shih Ni} and Su, {Fu Hsiung}",
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T1 - Association of Sjögrens syndrome in patients with chronic hepatitis virus infection

T2 - A population-based analysis

AU - Yeh, Chih Ching

AU - Wang, Wen Chang

AU - Wu, Chien Sheng

AU - Sung, Fung Chang

AU - Su, Chien Tien

AU - Shieh, Ying Hua

AU - Chang, Shih Ni

AU - Su, Fu Hsiung

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N2 - Objective: The association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections. Materials and Methods: We identified 9,629 SS patients without other concomitant autoimmune diseases and 38,516 sex- and age-matched controls without SS from the Taiwan National Health Insurance claims data between 2000 and 2011. We utilized multivariate logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between SS and HBV and HCV infections. Sex- and age-specific (<55 and ≥55 years) risks of SS were evaluated. Results: The risk of SS was higher in patients with HCV than in those without chronic viral hepatitis (OR = 2.49, 95% CI = 2.16-2.86). Conversely, HBV infection was not associated with SS (OR = 1.10, 95% CI = 0.98-1.24). Younger HCV patients were at a higher risk for SS (<55 years: OR = 3.37, 95% CI = 2.62-4.35; ≥55 years: OR = 2.20, 95% CI = 1.84-2.62). Men with HCV were at a greater risk for SS (women: OR = 2.26, 95% CI = 1.94-2.63; men: OR = 4.22, 95% CI = 2.90-6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61, 95% CI = 1.21-2.14). Conclusion: HCV infection was associated with SS; however, HBV only associated with SS in men.

AB - Objective: The association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections. Materials and Methods: We identified 9,629 SS patients without other concomitant autoimmune diseases and 38,516 sex- and age-matched controls without SS from the Taiwan National Health Insurance claims data between 2000 and 2011. We utilized multivariate logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between SS and HBV and HCV infections. Sex- and age-specific (<55 and ≥55 years) risks of SS were evaluated. Results: The risk of SS was higher in patients with HCV than in those without chronic viral hepatitis (OR = 2.49, 95% CI = 2.16-2.86). Conversely, HBV infection was not associated with SS (OR = 1.10, 95% CI = 0.98-1.24). Younger HCV patients were at a higher risk for SS (<55 years: OR = 3.37, 95% CI = 2.62-4.35; ≥55 years: OR = 2.20, 95% CI = 1.84-2.62). Men with HCV were at a greater risk for SS (women: OR = 2.26, 95% CI = 1.94-2.63; men: OR = 4.22, 95% CI = 2.90-6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61, 95% CI = 1.21-2.14). Conclusion: HCV infection was associated with SS; however, HBV only associated with SS in men.

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