Association of prior antiplatelet agents with mortality in sepsis patients: a nationwide population-based cohort study

Min Juei Tsai, Shuo Ming Ou, Chia Jen Shih, Pei wen Chao, Lan Fu Wang, Yu Ning Shih, Szu Yuan Li, Shu Chen Kuo, Yen Tao Hsu, Yung Tai Chen

研究成果: 雜誌貢獻文章

32 引文 斯高帕斯(Scopus)

摘要

Background: Antiplatelet agents are widely used for cardiovascular diseases, but their pleiotropic effects in sepsis are controversial. Objective: To investigate the association between antiplatelet agents and the survival benefit for sepsis patients. Design: A nationwide population-based cohort and nested case–control study. Setting: Taiwan National Health Insurance database. Participants: All patients (age ≥18 years) who were hospitalized for sepsis between January 2000 and December 2010. Measurements: Conditional logistic regression was used to adjust for confounding. Adjusted odd ratios (ORs) were used to compare the mortality rate due to sepsis in antiplatelet drug users and nonusers. Results: Of 683,421 included patients, 229,792 (33.6 %) patients died during hospitalization for sepsis, and the rest (64.4 %) survived to discharge. Use of antiplatelet agents before admission was associated with a lower risk of mortality in sepsis patients (aOR 0.82, 95 % confidence interval [CI] 0.81–0.83, P < 0.001). By using another case–control study design, the beneficial effect was more significant in current users (aOR 0.78, 95 % CI 0.76–0.79) than in recent users (aOR 0.88, 95 % CI 0.85–0.91), but was not significant in past users (aOR 1.00, 95 % CI 0.98–1.02). Limitations: Observational study. Conclusions: Prior use of antiplatelet agents was associated with a survival benefit in sepsis patients.
原文英語
頁(從 - 到)806-813
頁數8
期刊Intensive Care Medicine
41
發行號5
DOIs
出版狀態已發佈 - 五月 1 2015

    指紋

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

引用此

Tsai, M. J., Ou, S. M., Shih, C. J., Chao, P. W., Wang, L. F., Shih, Y. N., Li, S. Y., Kuo, S. C., Hsu, Y. T., & Chen, Y. T. (2015). Association of prior antiplatelet agents with mortality in sepsis patients: a nationwide population-based cohort study. Intensive Care Medicine, 41(5), 806-813. https://doi.org/10.1007/s00134-015-3760-y