Association of plasma folate, vitamin B12 levels, and arsenic methylation capacity with developmental delay in preschool children in Taiwan

Ying Chin Lin, Chi Jung Chung, Ya Li Huang, Ru Lan Hsieh, Pai Tsang Huang, Mei Yi Wu, Pui Lam Ao, Horng Sheng Shiue, Shiau Rung Huang, Chien Tien Su, Ming I. Lin, Shu Chi Mu, Yu Mei Hsueh

研究成果: 雜誌貢獻文章

摘要

Developmental delay has been associated with inefficient arsenic methylation capacity in preschool children. Folate and vitamin B12 are important nutrients that produce s-adenosylmethionine during single-carbon metabolism and provide methyl groups for arsenic methylation. The aim of the present study was to explore whether plasma folate and vitamin B12 levels influence arsenic methylation capacity and in turn are related to developmental delay in preschool children. A case–control study was conducted in 178 children with developmental delay and 88 normal children, who were recruited from Shin Kong Wu Ho-Su Memorial Teaching Hospital from August 2010 to March 2014. Arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV), and dimethylarsinic acid (DMAV) in the urine was determined by high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Plasma folate and vitamin B12 levels were measured using a SimulTRAC-SNB radioassay. The results show that the combination of high plasma folate and high vitamin B12 levels were correlated with efficient arsenic methylation capacity (low MMAV %, low InAs %, and high DMAV %). High MMAV % significantly increased and high DMAV % and secondary methylation index decreased the odds ratio (OR) of developmental delay in a dose-dependent manner in both low plasma folate and low vitamin B12 (low/low) groups; the multivariate OR and 95% confidence interval were 5.01 (0.83–30.06), 0.21 (0.04–1.23), and 0.20 (0.03–1.20), respectively. This is the first study to show that the combination of high plasma folate and high vitamin B12 levels increases arsenic methylation capacity and indirectly decreases the OR of developmental delay in preschool children.

原文英語
期刊Archives of Toxicology
DOIs
出版狀態接受/付印 - 一月 1 2019

指紋

Methylation
Arsenic
Preschool Children
Vitamin B 12
Taiwan
Folic Acid
Plasmas
Odds Ratio
Cacodylic Acid
Atomic absorption spectrometry
High performance liquid chromatography
Metabolism
Hydrides
Teaching Hospitals
Nutrients
Spectrum Analysis
Teaching
Carbon
High Pressure Liquid Chromatography
Urine

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

引用此文

@article{d49a1c36f3084643810622fa0196a98b,
title = "Association of plasma folate, vitamin B12 levels, and arsenic methylation capacity with developmental delay in preschool children in Taiwan",
abstract = "Developmental delay has been associated with inefficient arsenic methylation capacity in preschool children. Folate and vitamin B12 are important nutrients that produce s-adenosylmethionine during single-carbon metabolism and provide methyl groups for arsenic methylation. The aim of the present study was to explore whether plasma folate and vitamin B12 levels influence arsenic methylation capacity and in turn are related to developmental delay in preschool children. A case–control study was conducted in 178 children with developmental delay and 88 normal children, who were recruited from Shin Kong Wu Ho-Su Memorial Teaching Hospital from August 2010 to March 2014. Arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV), and dimethylarsinic acid (DMAV) in the urine was determined by high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Plasma folate and vitamin B12 levels were measured using a SimulTRAC-SNB radioassay. The results show that the combination of high plasma folate and high vitamin B12 levels were correlated with efficient arsenic methylation capacity (low MMAV {\%}, low InAs {\%}, and high DMAV {\%}). High MMAV {\%} significantly increased and high DMAV {\%} and secondary methylation index decreased the odds ratio (OR) of developmental delay in a dose-dependent manner in both low plasma folate and low vitamin B12 (low/low) groups; the multivariate OR and 95{\%} confidence interval were 5.01 (0.83–30.06), 0.21 (0.04–1.23), and 0.20 (0.03–1.20), respectively. This is the first study to show that the combination of high plasma folate and high vitamin B12 levels increases arsenic methylation capacity and indirectly decreases the OR of developmental delay in preschool children.",
keywords = "Arsenic, Arsenic methylation, Developmental delay, Folate, Vitamin B12",
author = "Lin, {Ying Chin} and Chung, {Chi Jung} and Huang, {Ya Li} and Hsieh, {Ru Lan} and Huang, {Pai Tsang} and Wu, {Mei Yi} and Ao, {Pui Lam} and Shiue, {Horng Sheng} and Huang, {Shiau Rung} and Su, {Chien Tien} and Lin, {Ming I.} and Mu, {Shu Chi} and Hsueh, {Yu Mei}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00204-019-02540-4",
language = "English",
journal = "Archiv fur Toxikologie",
issn = "0003-9446",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Association of plasma folate, vitamin B12 levels, and arsenic methylation capacity with developmental delay in preschool children in Taiwan

AU - Lin, Ying Chin

AU - Chung, Chi Jung

AU - Huang, Ya Li

AU - Hsieh, Ru Lan

AU - Huang, Pai Tsang

AU - Wu, Mei Yi

AU - Ao, Pui Lam

AU - Shiue, Horng Sheng

AU - Huang, Shiau Rung

AU - Su, Chien Tien

AU - Lin, Ming I.

AU - Mu, Shu Chi

AU - Hsueh, Yu Mei

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Developmental delay has been associated with inefficient arsenic methylation capacity in preschool children. Folate and vitamin B12 are important nutrients that produce s-adenosylmethionine during single-carbon metabolism and provide methyl groups for arsenic methylation. The aim of the present study was to explore whether plasma folate and vitamin B12 levels influence arsenic methylation capacity and in turn are related to developmental delay in preschool children. A case–control study was conducted in 178 children with developmental delay and 88 normal children, who were recruited from Shin Kong Wu Ho-Su Memorial Teaching Hospital from August 2010 to March 2014. Arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV), and dimethylarsinic acid (DMAV) in the urine was determined by high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Plasma folate and vitamin B12 levels were measured using a SimulTRAC-SNB radioassay. The results show that the combination of high plasma folate and high vitamin B12 levels were correlated with efficient arsenic methylation capacity (low MMAV %, low InAs %, and high DMAV %). High MMAV % significantly increased and high DMAV % and secondary methylation index decreased the odds ratio (OR) of developmental delay in a dose-dependent manner in both low plasma folate and low vitamin B12 (low/low) groups; the multivariate OR and 95% confidence interval were 5.01 (0.83–30.06), 0.21 (0.04–1.23), and 0.20 (0.03–1.20), respectively. This is the first study to show that the combination of high plasma folate and high vitamin B12 levels increases arsenic methylation capacity and indirectly decreases the OR of developmental delay in preschool children.

AB - Developmental delay has been associated with inefficient arsenic methylation capacity in preschool children. Folate and vitamin B12 are important nutrients that produce s-adenosylmethionine during single-carbon metabolism and provide methyl groups for arsenic methylation. The aim of the present study was to explore whether plasma folate and vitamin B12 levels influence arsenic methylation capacity and in turn are related to developmental delay in preschool children. A case–control study was conducted in 178 children with developmental delay and 88 normal children, who were recruited from Shin Kong Wu Ho-Su Memorial Teaching Hospital from August 2010 to March 2014. Arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV), and dimethylarsinic acid (DMAV) in the urine was determined by high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Plasma folate and vitamin B12 levels were measured using a SimulTRAC-SNB radioassay. The results show that the combination of high plasma folate and high vitamin B12 levels were correlated with efficient arsenic methylation capacity (low MMAV %, low InAs %, and high DMAV %). High MMAV % significantly increased and high DMAV % and secondary methylation index decreased the odds ratio (OR) of developmental delay in a dose-dependent manner in both low plasma folate and low vitamin B12 (low/low) groups; the multivariate OR and 95% confidence interval were 5.01 (0.83–30.06), 0.21 (0.04–1.23), and 0.20 (0.03–1.20), respectively. This is the first study to show that the combination of high plasma folate and high vitamin B12 levels increases arsenic methylation capacity and indirectly decreases the OR of developmental delay in preschool children.

KW - Arsenic

KW - Arsenic methylation

KW - Developmental delay

KW - Folate

KW - Vitamin B12

UR - http://www.scopus.com/inward/record.url?scp=85071504540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071504540&partnerID=8YFLogxK

U2 - 10.1007/s00204-019-02540-4

DO - 10.1007/s00204-019-02540-4

M3 - Article

C2 - 31473767

AN - SCOPUS:85071504540

JO - Archiv fur Toxikologie

JF - Archiv fur Toxikologie

SN - 0003-9446

ER -