Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome

Te Fa Chiu, Chih Huang Li, Chun Chuan Chen, Chien Hsiun Chen, Chien Jui Cheng, Yu Ting Yan, Ruey Bing Yang

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Background: Heat shock proteins (HSPs) act as chaperones and have a protective function in cardiovascular diseases. The clinical association of a novel small HSPB7 with cardiovascular disease, however, has not been reported. The aim of this study was to investigate the potential biological functions of HSPB7 and its relationship with acute coronary syndrome (ACS). Methods and Results: A mouse myocardial infarction (MI) model and samples from clinical human subjects were used to determine plasma HSPB7 concentration after acute MI. The associations of plasma HSPB7 concentration with ACS and other risk factors of coronary artery disease were analyzed. Plasma HSPB7 concentration was found to be rapidly elevated in mice after coronary artery ligation. In addition, plasma HSPB7 concentration was significantly higher in patients with ACS than in control patients with non-cardiac chest pain (5.1 ng/ml vs. 2.9 ng/ml, P<0.001). Plasma HSPB7 was detected as early as 1-3 h after the onset of symptoms and remained detectable up to 24 h. Furthermore, in patients presenting to the emergency department with acute chest pain, HSPB7 level was an independent risk factor of ACS (adjusted odds ratio, 7.44; 95% confidence interval: 1.91-28.93, P<0.01). Conclusions: HSPB7 is a potential early biomarker after MI and serves as an independent risk factor of ACS in patients with acute chest pain.

原文英語
頁(從 - 到)2226-2233
頁數8
期刊Circulation Journal
76
發行號9
DOIs
出版狀態已發佈 - 2012

ASJC Scopus subject areas

  • 心臟病學與心血管醫學

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