@article{07353b1f4b8345b2a9236cd7ad5b3c2e,
title = "Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples",
abstract = "Aim: To investigate the possible correlation of nucleophosmin/B23 expression with bladder carcinoma recurrence. Methods: Surgically-resected bladder tumors staged pTa to pT4 were examined for nucleophosmin/B23 expression by immuno-histochemistry. The study group consisted of 132 consecutive patients surgically treated at Chang Gung Memorial Hospital between December 1998 and November 1999. The mean follow up was 72 months (range: 48-84 months). Results: Nuclear nucleophosmin/B23 staining was detected in 96% of advanced stage and poorly-differentiated tumors. Higher nucleophosmin/B23 levels were linked to more advanced tumor stages, grades, poor prognosis, and likelihood of recurrence (P<0.05). The Cox multivariate analysis indicated the nucleophosmin/B23 expression as an independent indicator for tumor recurrence (P=0.009). Conclusion: The results suggest that nucleophosmin/B23 is a favorable prognostic indicator for bladder cancer. Nucleophosmin/B23 could be a useful molecular tumor marker for predicting bladder cancer recurrence.",
keywords = "Bladder carcinoma recurrence, Immunohistochemistry, Nucleophosmin/B23",
author = "Tsui, {Ke Hung} and Juang, {Horng Heng} and Lee, {Tsong Hai} and Chang, {Phei Lang} and Chen, {Chien Lun} and Yung, {Benjamin Yat Ming}",
year = "2008",
month = mar,
doi = "10.1111/j.1745-7254.2008.00747.x",
language = "English",
volume = "29",
pages = "364--370",
journal = "Acta Pharmacologica Sinica",
issn = "1671-4083",
publisher = "Nature Publishing Group",
number = "3",
}