Association of nucleophosmin/B23 mRNA expression with clinical outcome in patients with bladder carcinoma

Ke Hung Tsui, Ann Joy Cheng, Phei Lang Chang, Tai Long Pan, Benjamin Yat Ming Yung

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70 引文 斯高帕斯(Scopus)

摘要

To determine whether nucleophosmin/B23 mRNA expression in bladder carcinoma predicts recurrence, progression, and survival. Real-time reverse transcriptase-polymerase chain reaction was performed on 50 fresh cancer specimens. The change in the cycle of threshold (Ct)was the difference in the Ct values derived from the nucleophosmin/B23 gene assayed and the 18S ribosomal RNA control [Ct (18S) - Ct (nucleophosmin/B23)]. Fifty patients diagnosed with bladder cancer were followed up postoperatively for a median of 24 months. Overexpression of nucleophosmin/B23 mRNA was observed in 37.1% of patients with Stage pT1 and 73.3% of those with pT2-T4 disease. Nucleophosmin/B23 overexpression was not associated with tumor grade (P = 0.163) but was associated with bladder cancer recurrence (68.2%) and progression (88.9%) when adjusted for the effects of clinical stage. Multivariate analysis revealed that the overall tumor stage and nucleophosmin/B23 mRNA overexpression were important prognostic indicators for bladder carcinoma (P
原文英語
頁(從 - 到)839-844
頁數6
期刊Urology
64
發行號4
DOIs
出版狀態已發佈 - 10月 2004
對外發佈

ASJC Scopus subject areas

  • 泌尿科學

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