Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan

Yun Pung P. Hsu, El W. Loh, Wei J. Chen, Chiao Chicy Chen, Jeng Ming Yu, Andrew T.A. Cheng

研究成果: 雜誌貢獻文章同行評審

60 引文 斯高帕斯(Scopus)

摘要

Objective: The role of monoamine oxidase (MAO) in alcoholism was assessed by genetic association studies separately in five ethnic groups in Taiwan. Method: Restriction fragment length polymorphisms (RHLP) and dinucleotide repeat polymorphisms (DNRP) were used to determine MAOA and MAOB alleles in male alcoholic patients and nonalcoholic comparison subjects among Han Chinese and four aboriginal groups. Results: Significant associations of alcohol dependence with MAOA alleles (RFLP and DNRP) were found among the Han Chinese, but not among the aboriginal groups. No significant association with MAOB DNRP alleles was found in any group. Conclusions: Genetic heterogeneity may underlie alcoholism among different ethnic groups in Taiwan, and MAOA mutations may play a role in susceptibility to alcoholism among Han Chinese.

原文英語
頁(從 - 到)1209-1211
頁數3
期刊American Journal of Psychiatry
153
發行號9
DOIs
出版狀態已發佈 - 一月 1 1996
對外發佈

ASJC Scopus subject areas

  • 精神病學和心理健康

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