Association of Meniere disease with human leukocyte antigen in Taiwanese population

Kai Chieh Chan, Che Ming Wu, Wan Ling Ho, Ping Chin Lai

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

The etiology of Ménière disease (MD) is multifactorial; genetic factors seem to play an important role. The associations between MD and human leukocyte antigen (HLA) status have been studied previously in several populations and have shown that the HLA alleles imparting susceptibility varied. In the present study, we explored HLA status in Taiwanese patients with definitive MD. HLA was typed via polymerase chain reaction, sequence-specific oligonucleotide genotyping in 35 patients with MD diagnosed using the criteria of the American Academy of Otolaryngology-Head and Neck Surgery and 70 unrelated healthy controls. HLA allele association tests were used to evaluate differences in allelic frequencies between the patients and controls. The allelic frequency of HLAA 11 was significantly greater in MD patients than in controls (52.9 vs. 31.4%, odds ratio: 2.45, 95% confidence interval: 1.4 to 4.4, p = 0.004, p corrected = 0.03). Thus, A11 may be a useful HLA biomarker in Taiwanese patients with MD. Further larger-scale studies are required.

原文英語
頁(從 - 到)396-402
頁數7
期刊Ear, Nose and Throat Journal
97
發行號12
DOIs
出版狀態已發佈 - 12月 1 2018
對外發佈

ASJC Scopus subject areas

  • 耳鼻咽喉科

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