Association of matrix metalloproteinase-7 genotypes to the risk of oral cancer in Taiwan

Liang Chun Shih, Ching Hao Li, Kuo Ting Sun, Liang Yu Chen, Che Lun Hsu, Yi Wen Hung, Cheng Nan Wu, Te Chun Hsia, Te Chun Shen, Wen Shin Chang, Tzu Ching Shih, Chia Wen Tsai, Da Tian Bau

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

Background/Aim: Matrix metalloproteinases (MMPs) play a critical role in inflammation and carcinogenesis, and the expression of mRNA MMP7 in oral squamous cell carcinoma tissues was higher than in the oral lichen planus or normal oral mucosa. However, the genotypic role of MMP7 has never been examined in oral cancer. Therefore, in the current study we aimed to examine the contribution of genotypic variants in the promoter region of MMP7 (A-181G and C-153T) to oral cancer risk in Taiwan. Materials and Methods: In this hospital-based case–control study, 788 patients with oral cancer and 956 gender-and age-matched healthy controls were genotyped for MMP7 A-181G and C-153T via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results: The distribution pattern of AA, AG and GG for MMP7 promoter A-181G genotype was 88.2, 10.4 and 1.4% in the oral cancer patient group and 89.0, 9.3 and 1.7% in the healthy control group, respectively (p for trend=0.6779),non-significantly differentially distributed between the two groups. There is no polymorphic genotype for MMP7 C-153T among Taiwanese. The omparisons in allelic frequency distribution also support the findings that G allele may not be the risk determinant allele for oral cancer. There is no interaction between the genotypes of MMP7 with age, gender, smoking, alcohol or betel quid consumption on oral cancer risk. Conclusion: Our results indicate that the MMP7 promoter genotypes only play an indirect role in determining the personal susceptibility to oral cancer in Taiwan.
原文英語
頁(從 - 到)2087-2092
頁數6
期刊Anticancer Research
38
發行號4
DOIs
出版狀態已發佈 - 四月 2018

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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