摘要

This study was aimed to evaluate the correlation between the polymorphisms of the UDP-glucuronosyltransferases1A7 (UGT1A7) gene and the risk of lung carcinogenesis in the Taiwanese population. A total of 230 lung cancer patients and 230 age- and gender-matched healthy individuals were enrolled in this case control study. UGT1A7*1 was defined as a high activity allele, while UGT1A7*2, UGT1A7*3 and UGT1A7*4 were categorized as low activity alleles. The relationship between EGFR mutations and UGT1A7 polymorphisms was investigated in this study. The frequency of UGT1A7*2 and UGT1A7*3 was significantly higher in the lung cancer group than in the control group (p = 0.03, odds ratio (OR) = 1.44, 95% confidence interval (CI) = 1.04-1.99 for UGT1A7*2; and p = 0.01, OR = 1.56, 95% CI = 1.11-2.18 for UGT1A7*3). The frequency of lower activity alleles was significantly higher in the lung cancer group than in the control group (p = 0.03, OR = 1.58, 95% CI = 1.04-2.40 for the high-activity allele/low-activity allele (H/L) group; and p <0.01, OR = 2.23, 95% CI = 1.29-3.84 for the low-activity allele/low-activity allele (L/L) group). This difference was only significant in the male subgroup, with odds ratio of 1.87 (95% CI = 1.05-3.36, p = 0.03) for the H/L group and 2.638 (95% CI = 1.28-5.42, p <0.01) for the L/L allele group. Yet, pathologic type and epidermal growth factor receptor (EGFR) mutations did not affect the distribution of UGT1A7 in the patient group. The results suggested that the polymorphisms of the metabolic gene, UGT1A7, may contribute to reduced enzyme activity and subsequently affect the detoxification of carcinogens. It is therefore concluded that UGT1A7 polymorphism is associated with lung carcinogenesis for the Taiwanese population.
原文英語
頁(從 - 到)403-409
期刊Journal of Food and Drug Analysis
19
發行號4
出版狀態已發佈 - 十二月 2011

指紋

Uridine Diphosphate
lung neoplasms
case-control studies
Taiwan
Case-Control Studies
Lung Neoplasms
alleles
confidence interval
odds ratio
Alleles
genetic polymorphism
Confidence Intervals
Odds Ratio
carcinogenesis
lungs
mutation
Epidermal Growth Factor Receptor
Carcinogenesis
carcinogens
Lung

ASJC Scopus subject areas

  • Food Science
  • Pharmacology

引用此文

@article{355bec3ab8d0476e998c7b0438cc57fa,
title = "Association of low activity of UGT1A7 with Lung Cancer in Taiwan: A preliminary case control study",
abstract = "This study was aimed to evaluate the correlation between the polymorphisms of the UDP-glucuronosyltransferases1A7 (UGT1A7) gene and the risk of lung carcinogenesis in the Taiwanese population. A total of 230 lung cancer patients and 230 age- and gender-matched healthy individuals were enrolled in this case control study. UGT1A7*1 was defined as a high activity allele, while UGT1A7*2, UGT1A7*3 and UGT1A7*4 were categorized as low activity alleles. The relationship between EGFR mutations and UGT1A7 polymorphisms was investigated in this study. The frequency of UGT1A7*2 and UGT1A7*3 was significantly higher in the lung cancer group than in the control group (p = 0.03, odds ratio (OR) = 1.44, 95{\%} confidence interval (CI) = 1.04-1.99 for UGT1A7*2; and p = 0.01, OR = 1.56, 95{\%} CI = 1.11-2.18 for UGT1A7*3). The frequency of lower activity alleles was significantly higher in the lung cancer group than in the control group (p = 0.03, OR = 1.58, 95{\%} CI = 1.04-2.40 for the high-activity allele/low-activity allele (H/L) group; and p <0.01, OR = 2.23, 95{\%} CI = 1.29-3.84 for the low-activity allele/low-activity allele (L/L) group). This difference was only significant in the male subgroup, with odds ratio of 1.87 (95{\%} CI = 1.05-3.36, p = 0.03) for the H/L group and 2.638 (95{\%} CI = 1.28-5.42, p <0.01) for the L/L allele group. Yet, pathologic type and epidermal growth factor receptor (EGFR) mutations did not affect the distribution of UGT1A7 in the patient group. The results suggested that the polymorphisms of the metabolic gene, UGT1A7, may contribute to reduced enzyme activity and subsequently affect the detoxification of carcinogens. It is therefore concluded that UGT1A7 polymorphism is associated with lung carcinogenesis for the Taiwanese population.",
keywords = "EGFR mutation, Enzyme, Gene, Lung cancer, Risk factor, UGT1A7 polymorphisms",
author = "Lee, {Jen Ai} and Liu, {H. Eugene} and Huang, {Wei I.} and Chun-Nin Lee and Yu, {Ming Chih} and Bai, {Kuan Jen} and Chang, {Jer Hua} and Hsu, {Han Lin} and Lu, {Pei Chih} and Chen, {Hsiang Yin}",
year = "2011",
month = "12",
language = "English",
volume = "19",
pages = "403--409",
journal = "Journal of Food and Drug Analysis",
issn = "1021-9498",
publisher = "Elsevier Taiwan LLC",
number = "4",

}

TY - JOUR

T1 - Association of low activity of UGT1A7 with Lung Cancer in Taiwan

T2 - A preliminary case control study

AU - Lee, Jen Ai

AU - Liu, H. Eugene

AU - Huang, Wei I.

AU - Lee, Chun-Nin

AU - Yu, Ming Chih

AU - Bai, Kuan Jen

AU - Chang, Jer Hua

AU - Hsu, Han Lin

AU - Lu, Pei Chih

AU - Chen, Hsiang Yin

PY - 2011/12

Y1 - 2011/12

N2 - This study was aimed to evaluate the correlation between the polymorphisms of the UDP-glucuronosyltransferases1A7 (UGT1A7) gene and the risk of lung carcinogenesis in the Taiwanese population. A total of 230 lung cancer patients and 230 age- and gender-matched healthy individuals were enrolled in this case control study. UGT1A7*1 was defined as a high activity allele, while UGT1A7*2, UGT1A7*3 and UGT1A7*4 were categorized as low activity alleles. The relationship between EGFR mutations and UGT1A7 polymorphisms was investigated in this study. The frequency of UGT1A7*2 and UGT1A7*3 was significantly higher in the lung cancer group than in the control group (p = 0.03, odds ratio (OR) = 1.44, 95% confidence interval (CI) = 1.04-1.99 for UGT1A7*2; and p = 0.01, OR = 1.56, 95% CI = 1.11-2.18 for UGT1A7*3). The frequency of lower activity alleles was significantly higher in the lung cancer group than in the control group (p = 0.03, OR = 1.58, 95% CI = 1.04-2.40 for the high-activity allele/low-activity allele (H/L) group; and p <0.01, OR = 2.23, 95% CI = 1.29-3.84 for the low-activity allele/low-activity allele (L/L) group). This difference was only significant in the male subgroup, with odds ratio of 1.87 (95% CI = 1.05-3.36, p = 0.03) for the H/L group and 2.638 (95% CI = 1.28-5.42, p <0.01) for the L/L allele group. Yet, pathologic type and epidermal growth factor receptor (EGFR) mutations did not affect the distribution of UGT1A7 in the patient group. The results suggested that the polymorphisms of the metabolic gene, UGT1A7, may contribute to reduced enzyme activity and subsequently affect the detoxification of carcinogens. It is therefore concluded that UGT1A7 polymorphism is associated with lung carcinogenesis for the Taiwanese population.

AB - This study was aimed to evaluate the correlation between the polymorphisms of the UDP-glucuronosyltransferases1A7 (UGT1A7) gene and the risk of lung carcinogenesis in the Taiwanese population. A total of 230 lung cancer patients and 230 age- and gender-matched healthy individuals were enrolled in this case control study. UGT1A7*1 was defined as a high activity allele, while UGT1A7*2, UGT1A7*3 and UGT1A7*4 were categorized as low activity alleles. The relationship between EGFR mutations and UGT1A7 polymorphisms was investigated in this study. The frequency of UGT1A7*2 and UGT1A7*3 was significantly higher in the lung cancer group than in the control group (p = 0.03, odds ratio (OR) = 1.44, 95% confidence interval (CI) = 1.04-1.99 for UGT1A7*2; and p = 0.01, OR = 1.56, 95% CI = 1.11-2.18 for UGT1A7*3). The frequency of lower activity alleles was significantly higher in the lung cancer group than in the control group (p = 0.03, OR = 1.58, 95% CI = 1.04-2.40 for the high-activity allele/low-activity allele (H/L) group; and p <0.01, OR = 2.23, 95% CI = 1.29-3.84 for the low-activity allele/low-activity allele (L/L) group). This difference was only significant in the male subgroup, with odds ratio of 1.87 (95% CI = 1.05-3.36, p = 0.03) for the H/L group and 2.638 (95% CI = 1.28-5.42, p <0.01) for the L/L allele group. Yet, pathologic type and epidermal growth factor receptor (EGFR) mutations did not affect the distribution of UGT1A7 in the patient group. The results suggested that the polymorphisms of the metabolic gene, UGT1A7, may contribute to reduced enzyme activity and subsequently affect the detoxification of carcinogens. It is therefore concluded that UGT1A7 polymorphism is associated with lung carcinogenesis for the Taiwanese population.

KW - EGFR mutation

KW - Enzyme

KW - Gene

KW - Lung cancer

KW - Risk factor

KW - UGT1A7 polymorphisms

UR - http://www.scopus.com/inward/record.url?scp=84863131841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863131841&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 403

EP - 409

JO - Journal of Food and Drug Analysis

JF - Journal of Food and Drug Analysis

SN - 1021-9498

IS - 4

ER -