Association of IS605 and cag -PAI of helicobacter pylori isolated from patients with gastrointestinal diseases in Taiwan

Chih Ho Lai, Chin Lin Perng, Keng Hsin Lan, Hwai Jeng Lin

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11 引文 斯高帕斯(Scopus)

摘要

Background. The cag pathogenicity island (cag-PAI) is one of the most important virulent determinants of Helicobacter pylori. An insertion sequence (IS) element of cag-PAI (IS605) has been found to generate H. pylori strains with varying virulence. Aim. To evaluate the impact of IS605 and cag-PAI on H. pylori strains isolated from Taiwanese patients with severity of gastric diseases. Methods. H. pylori isolates were cultured from gastric biopsies from 99 patients with peptic ulcer, chronic gastritis, and gastric carcinoma. Six distinct, well-separated colonies were isolated from each patient and analyzed by genotyping. Results. cagA, cagE, cagM, cagT, orf10, and orf13 were found to be present in 90.0%-100.0% of the H. pylori isolates. A total deletion of cagA, cagE, cagM, cagT, orf10, and orf13 was found in 1 isolate (1.0%). The IS605 element was found to be positive in 15.2% of the isolates. The presence of IS605 was higher in H. pylori isolated from patients with gastric carcinoma (25.0%) than in patients with duodenal ulcer (6.5%) or chronic gastritis (6.3%) (P

原文英語
文章編號356217
期刊Gastroenterology Research and Practice
2013
DOIs
出版狀態已發佈 - 2013

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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