Association of high body lead store with severe intracranial carotid atherosclerosis

Tsong Hai Lee, Mei Chun Tseng, Chi Jen Chen, Ja Liang Lin

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Objective: Lead is involved in the pathogenesis of atherosclerosis and hypertensive disease and may be related to cerebrovascular disease. We studied the association of body lead level with stroke subtypes and severity of cerebral atherosclerosis in order to identify the significance of lead exposure to cerebrovascular disease. Methods: From April, 2002 to March, 2005, we studied the lead level in all patients receiving digital subtraction angiography. Diameter stenosis at extracranial carotid, intracranial carotid and vertebrobasilar system was calculated according to the NASCET criteria. A blood sample and a mobilization test of 72-h urine sample were collected for lead measurement. Results: In a total of 213 subjects, 19 were free of stroke (blood lead level = 4.62 ± 2.41 μg/dL, body lead store = 39.04 ± 20.91 μg) and 194 were stroke patients (4.89 ± 2.75 μg/dL, 45.13 ± 29.8 μg; all stroke vs. non-stroke, P > 0.05). In the 153 subjects with atherosclerotic origin, body lead store but not blood lead level in the intracranial carotid system was significantly higher in ≥50% group than 0.05). Conclusion: Our study demonstrated that long-term lead exposure as measured by body lead store might carry a potential risk of intracranial carotid atherosclerosis.

原文英語
頁(從 - 到)876-880
頁數5
期刊NeuroToxicology
30
發行號6
DOIs
出版狀態已發佈 - 十一月 2009

指紋

Intracranial Arteriosclerosis
Carotid Artery Diseases
Stroke
Cerebrovascular Disorders
Blood
Digital Subtraction Angiography
Angiography
Lead
Atherosclerosis
Pathologic Constriction
Urine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

引用此文

Association of high body lead store with severe intracranial carotid atherosclerosis. / Lee, Tsong Hai; Tseng, Mei Chun; Chen, Chi Jen; Lin, Ja Liang.

於: NeuroToxicology, 卷 30, 編號 6, 11.2009, p. 876-880.

研究成果: 雜誌貢獻文章

Lee, Tsong Hai ; Tseng, Mei Chun ; Chen, Chi Jen ; Lin, Ja Liang. / Association of high body lead store with severe intracranial carotid atherosclerosis. 於: NeuroToxicology. 2009 ; 卷 30, 編號 6. 頁 876-880.
@article{360539ddd81842bd95defcb0a48af36b,
title = "Association of high body lead store with severe intracranial carotid atherosclerosis",
abstract = "Objective: Lead is involved in the pathogenesis of atherosclerosis and hypertensive disease and may be related to cerebrovascular disease. We studied the association of body lead level with stroke subtypes and severity of cerebral atherosclerosis in order to identify the significance of lead exposure to cerebrovascular disease. Methods: From April, 2002 to March, 2005, we studied the lead level in all patients receiving digital subtraction angiography. Diameter stenosis at extracranial carotid, intracranial carotid and vertebrobasilar system was calculated according to the NASCET criteria. A blood sample and a mobilization test of 72-h urine sample were collected for lead measurement. Results: In a total of 213 subjects, 19 were free of stroke (blood lead level = 4.62 ± 2.41 μg/dL, body lead store = 39.04 ± 20.91 μg) and 194 were stroke patients (4.89 ± 2.75 μg/dL, 45.13 ± 29.8 μg; all stroke vs. non-stroke, P > 0.05). In the 153 subjects with atherosclerotic origin, body lead store but not blood lead level in the intracranial carotid system was significantly higher in ≥50{\%} group than 0.05). Conclusion: Our study demonstrated that long-term lead exposure as measured by body lead store might carry a potential risk of intracranial carotid atherosclerosis.",
keywords = "Angiography, Atherosclerosis, Carotid artery, Lead, Stroke",
author = "Lee, {Tsong Hai} and Tseng, {Mei Chun} and Chen, {Chi Jen} and Lin, {Ja Liang}",
year = "2009",
month = "11",
doi = "10.1016/j.neuro.2009.07.004",
language = "English",
volume = "30",
pages = "876--880",
journal = "NeuroToxicology",
issn = "0161-813X",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Association of high body lead store with severe intracranial carotid atherosclerosis

AU - Lee, Tsong Hai

AU - Tseng, Mei Chun

AU - Chen, Chi Jen

AU - Lin, Ja Liang

PY - 2009/11

Y1 - 2009/11

N2 - Objective: Lead is involved in the pathogenesis of atherosclerosis and hypertensive disease and may be related to cerebrovascular disease. We studied the association of body lead level with stroke subtypes and severity of cerebral atherosclerosis in order to identify the significance of lead exposure to cerebrovascular disease. Methods: From April, 2002 to March, 2005, we studied the lead level in all patients receiving digital subtraction angiography. Diameter stenosis at extracranial carotid, intracranial carotid and vertebrobasilar system was calculated according to the NASCET criteria. A blood sample and a mobilization test of 72-h urine sample were collected for lead measurement. Results: In a total of 213 subjects, 19 were free of stroke (blood lead level = 4.62 ± 2.41 μg/dL, body lead store = 39.04 ± 20.91 μg) and 194 were stroke patients (4.89 ± 2.75 μg/dL, 45.13 ± 29.8 μg; all stroke vs. non-stroke, P > 0.05). In the 153 subjects with atherosclerotic origin, body lead store but not blood lead level in the intracranial carotid system was significantly higher in ≥50% group than 0.05). Conclusion: Our study demonstrated that long-term lead exposure as measured by body lead store might carry a potential risk of intracranial carotid atherosclerosis.

AB - Objective: Lead is involved in the pathogenesis of atherosclerosis and hypertensive disease and may be related to cerebrovascular disease. We studied the association of body lead level with stroke subtypes and severity of cerebral atherosclerosis in order to identify the significance of lead exposure to cerebrovascular disease. Methods: From April, 2002 to March, 2005, we studied the lead level in all patients receiving digital subtraction angiography. Diameter stenosis at extracranial carotid, intracranial carotid and vertebrobasilar system was calculated according to the NASCET criteria. A blood sample and a mobilization test of 72-h urine sample were collected for lead measurement. Results: In a total of 213 subjects, 19 were free of stroke (blood lead level = 4.62 ± 2.41 μg/dL, body lead store = 39.04 ± 20.91 μg) and 194 were stroke patients (4.89 ± 2.75 μg/dL, 45.13 ± 29.8 μg; all stroke vs. non-stroke, P > 0.05). In the 153 subjects with atherosclerotic origin, body lead store but not blood lead level in the intracranial carotid system was significantly higher in ≥50% group than 0.05). Conclusion: Our study demonstrated that long-term lead exposure as measured by body lead store might carry a potential risk of intracranial carotid atherosclerosis.

KW - Angiography

KW - Atherosclerosis

KW - Carotid artery

KW - Lead

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=71349085779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71349085779&partnerID=8YFLogxK

U2 - 10.1016/j.neuro.2009.07.004

DO - 10.1016/j.neuro.2009.07.004

M3 - Article

C2 - 19616024

AN - SCOPUS:71349085779

VL - 30

SP - 876

EP - 880

JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

IS - 6

ER -