Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals

Meei Maan Wu, Hung Yi Chiou, Chi Ling Chen, Ling I. Hsu, Li Ming Lien, Chih Hao Wang, Yi Chen Hsieh, Yuan Hung Wang, Yu Mei Hsueh, Te Chang Lee, Wen Fang Cheng, Chien Jen Chen

研究成果: 雜誌貢獻文章

20 引文 斯高帕斯(Scopus)

摘要

Objective: Heme oxygenase (HO)-1 is up-regulated as a cellular defense responding to stressful stimuli in experimental studies. A GT-repeat length polymorphism in the HO-1 gene promoter was inversely correlated to HO-1 induction. Here, we reported the association of GT-repeat polymorphism with blood pressure (BP) phenotypes, and their interaction on cardiovascular (CV) mortality risk in arsenic-exposed cohorts. Methods: Associations of GT-repeat polymorphism with BP phenotypes were investigated at baseline in a cross-sectional design. Effect of GT-repeat polymorphism on CV mortality was investigated in a longitudinal design stratified by hypertension. GT-repeat variants were grouped by S (
原文英語
頁(從 - 到)704-708
頁數5
期刊Atherosclerosis
219
發行號2
DOIs
出版狀態已發佈 - 十二月 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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