Association of expression of Kruppel-like factor 4 and Kruppel-like factor 5 with the clinical manifestations of breast cancer

Chih Jung Chen, Sey-En Lin, Yueh Min Lin, Shu Hui Lin, Dar Ren Chen, Chi Long Chen

研究成果: 雜誌貢獻文章

19 引文 (Scopus)

摘要

Kruppel-like factors (KLFs) are import modulators of cell proliferation, differentiation, and transformation and have recently been considered possible prognostic factors in breast cancer. In this study, we investigated the correlation between KLF4 and KLF5 expression and the clinical manifestations of breast cancer by immunohistochemical analysis. We observed increased KLF4 and KLF5 expression in tumor cells (invasive and in situ carcinomas), consistent KLF4 and KLF5 expression in in situ and invasive carcinomas, significant associations between KLF4 expression and tumor grade (p=0.033), size (p=0.035) and stage (p=0.006), and an association between KLF5 expression and tumor grade (p=0.033). Interestingly, we observed a relationship between increasing age and KLF4 expression (p=0.007), with a tendency towards greater expression in tumor cells in patients over 50 years old. Moreover, KLF5 nuclear localization was restricted to non-tumor breast ducts and lobules; however, loss of nuclear expression of KLF5 in in situ and invasive carcinomas was observed. Although the mechanism of the loss of KLF5 nuclear expression is not clear, this phenomenon may imply a possible tumorsuppressor-like role for KLF5 in breast cancer tumorigenesis. The expression of KLF4 and KLF5 in breast cancer patients in Taiwan is similar to that in Western countries, except for the uncertainty surrounding its prognostic significance. Further clarification of the underlying mechanisms of KLF4 and KLF5 expression and their correlations with breast cancer outcomes is necessary.
原文英語
頁(從 - 到)161-168
頁數8
期刊Pathology and Oncology Research
18
發行號2
DOIs
出版狀態已發佈 - 四月 2012

指紋

Kruppel-Like Transcription Factors
Breast Neoplasms
Carcinoma in Situ
Neoplasms
Taiwan
Uncertainty
Cell Differentiation
Carcinogenesis
Breast
Cell Proliferation
GKLF protein

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

引用此文

Association of expression of Kruppel-like factor 4 and Kruppel-like factor 5 with the clinical manifestations of breast cancer. / Chen, Chih Jung; Lin, Sey-En; Lin, Yueh Min; Lin, Shu Hui; Chen, Dar Ren; Chen, Chi Long.

於: Pathology and Oncology Research, 卷 18, 編號 2, 04.2012, p. 161-168.

研究成果: 雜誌貢獻文章

@article{8ec6de63790944629ef2c2b8a36fccb0,
title = "Association of expression of Kruppel-like factor 4 and Kruppel-like factor 5 with the clinical manifestations of breast cancer",
abstract = "Kruppel-like factors (KLFs) are import modulators of cell proliferation, differentiation, and transformation and have recently been considered possible prognostic factors in breast cancer. In this study, we investigated the correlation between KLF4 and KLF5 expression and the clinical manifestations of breast cancer by immunohistochemical analysis. We observed increased KLF4 and KLF5 expression in tumor cells (invasive and in situ carcinomas), consistent KLF4 and KLF5 expression in in situ and invasive carcinomas, significant associations between KLF4 expression and tumor grade (p=0.033), size (p=0.035) and stage (p=0.006), and an association between KLF5 expression and tumor grade (p=0.033). Interestingly, we observed a relationship between increasing age and KLF4 expression (p=0.007), with a tendency towards greater expression in tumor cells in patients over 50 years old. Moreover, KLF5 nuclear localization was restricted to non-tumor breast ducts and lobules; however, loss of nuclear expression of KLF5 in in situ and invasive carcinomas was observed. Although the mechanism of the loss of KLF5 nuclear expression is not clear, this phenomenon may imply a possible tumorsuppressor-like role for KLF5 in breast cancer tumorigenesis. The expression of KLF4 and KLF5 in breast cancer patients in Taiwan is similar to that in Western countries, except for the uncertainty surrounding its prognostic significance. Further clarification of the underlying mechanisms of KLF4 and KLF5 expression and their correlations with breast cancer outcomes is necessary.",
keywords = "Breast cancer, Immunohistochemistry, KLF4, KLF5, Kruppel-like factor",
author = "Chen, {Chih Jung} and Sey-En Lin and Lin, {Yueh Min} and Lin, {Shu Hui} and Chen, {Dar Ren} and Chen, {Chi Long}",
year = "2012",
month = "4",
doi = "10.1007/s12253-011-9422-7",
language = "English",
volume = "18",
pages = "161--168",
journal = "Pathology and Oncology Research",
issn = "1219-4956",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - Association of expression of Kruppel-like factor 4 and Kruppel-like factor 5 with the clinical manifestations of breast cancer

AU - Chen, Chih Jung

AU - Lin, Sey-En

AU - Lin, Yueh Min

AU - Lin, Shu Hui

AU - Chen, Dar Ren

AU - Chen, Chi Long

PY - 2012/4

Y1 - 2012/4

N2 - Kruppel-like factors (KLFs) are import modulators of cell proliferation, differentiation, and transformation and have recently been considered possible prognostic factors in breast cancer. In this study, we investigated the correlation between KLF4 and KLF5 expression and the clinical manifestations of breast cancer by immunohistochemical analysis. We observed increased KLF4 and KLF5 expression in tumor cells (invasive and in situ carcinomas), consistent KLF4 and KLF5 expression in in situ and invasive carcinomas, significant associations between KLF4 expression and tumor grade (p=0.033), size (p=0.035) and stage (p=0.006), and an association between KLF5 expression and tumor grade (p=0.033). Interestingly, we observed a relationship between increasing age and KLF4 expression (p=0.007), with a tendency towards greater expression in tumor cells in patients over 50 years old. Moreover, KLF5 nuclear localization was restricted to non-tumor breast ducts and lobules; however, loss of nuclear expression of KLF5 in in situ and invasive carcinomas was observed. Although the mechanism of the loss of KLF5 nuclear expression is not clear, this phenomenon may imply a possible tumorsuppressor-like role for KLF5 in breast cancer tumorigenesis. The expression of KLF4 and KLF5 in breast cancer patients in Taiwan is similar to that in Western countries, except for the uncertainty surrounding its prognostic significance. Further clarification of the underlying mechanisms of KLF4 and KLF5 expression and their correlations with breast cancer outcomes is necessary.

AB - Kruppel-like factors (KLFs) are import modulators of cell proliferation, differentiation, and transformation and have recently been considered possible prognostic factors in breast cancer. In this study, we investigated the correlation between KLF4 and KLF5 expression and the clinical manifestations of breast cancer by immunohistochemical analysis. We observed increased KLF4 and KLF5 expression in tumor cells (invasive and in situ carcinomas), consistent KLF4 and KLF5 expression in in situ and invasive carcinomas, significant associations between KLF4 expression and tumor grade (p=0.033), size (p=0.035) and stage (p=0.006), and an association between KLF5 expression and tumor grade (p=0.033). Interestingly, we observed a relationship between increasing age and KLF4 expression (p=0.007), with a tendency towards greater expression in tumor cells in patients over 50 years old. Moreover, KLF5 nuclear localization was restricted to non-tumor breast ducts and lobules; however, loss of nuclear expression of KLF5 in in situ and invasive carcinomas was observed. Although the mechanism of the loss of KLF5 nuclear expression is not clear, this phenomenon may imply a possible tumorsuppressor-like role for KLF5 in breast cancer tumorigenesis. The expression of KLF4 and KLF5 in breast cancer patients in Taiwan is similar to that in Western countries, except for the uncertainty surrounding its prognostic significance. Further clarification of the underlying mechanisms of KLF4 and KLF5 expression and their correlations with breast cancer outcomes is necessary.

KW - Breast cancer

KW - Immunohistochemistry

KW - KLF4

KW - KLF5

KW - Kruppel-like factor

UR - http://www.scopus.com/inward/record.url?scp=84863492022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863492022&partnerID=8YFLogxK

U2 - 10.1007/s12253-011-9422-7

DO - 10.1007/s12253-011-9422-7

M3 - Article

C2 - 21674249

AN - SCOPUS:84863492022

VL - 18

SP - 161

EP - 168

JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

SN - 1219-4956

IS - 2

ER -