Association of blood heavy metals with developmental delays and health status in children

Yu Mei Hsueh, Chih Ying Lee, Ssu Ning Chien, Wei Jen Chen, Horng Sheng Shiue, Shiau Rung Huang, Ming I. Lin, Shu Chi Mu, Ru Lan Hsieh

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

The aim of this study was to evaluate the association of blood lead, mercury, and cadmium concentrations with developmental delays and to explore the association of these concentrations with the health status of children. This study recruited 89 children with developmental delays and 89 age-and sex-matched children with typical development. Their health status was evaluated using the Pediatric Quality of Life (PedsQL) Inventory for health-related quality of life (HRQOL) and the Pediatric Outcomes Data Collection Instrument for function. Family function was also evaluated. Blood lead, mercury, and cadmium concentrations were measured using inductively coupled mass spectrometry. The children with developmental delays had a considerably poorer HRQOL, lower functional performance and family function, and a higher blood lead concentration than those with typical development. The blood lead concentration had a significantly positive association with developmental delays [odds ratio (OR) = 1.54, p < 0.01] in a dose-response manner, and it negatively correlated with PedsQL scores (regression coefficient:-0. 47 to-0.53, p < 0.05) in all the children studied. The higher blood cadmium concentration showed a significantly positive association with developmental delays (OR = 2.24, for >1.0 μg/L vs. <0.6 μg/L, p < 0.05). The blood mercury concentration was not associated with developmental delays and health status.
原文英語
文章編號43608
期刊Scientific Reports
7
DOIs
出版狀態已發佈 - 三月 2 2017

ASJC Scopus subject areas

  • General

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    Hsueh, Y. M., Lee, C. Y., Chien, S. N., Chen, W. J., Shiue, H. S., Huang, S. R., Lin, M. I., Mu, S. C., & Hsieh, R. L. (2017). Association of blood heavy metals with developmental delays and health status in children. Scientific Reports, 7, [43608]. https://doi.org/10.1038/srep43608