Association of Arsenic Methylation Capacity with Developmental Delays and Health Status in Children: A Prospective Case-Control Trial

Yu Mei Hsueh, Wei Jen Chen, Chih Ying Lee, Ssu Ning Chien, Horng Sheng Shiue, Shiau Rung Huang, Ming I. Lin, Shu Chi Mu, Ru Lan Hsieh

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

This case-control study identified the association between the arsenic methylation capacity and developmental delays and explored the association of this capacity with the health status of children. We recruited 120 children with developmental delays and 120 age-and sex-matched children without developmental delays. The health status of the children was assessed using the Pediatric Quality of Life Inventory (PedsQL) and Pediatric Outcomes Data Collection Instrument (PODCI). The arsenic methylation capacity was determined by the percentages of inorganic arsenic (InAs%), monomethylarsonic acid (MMA V %), and dimethylarsinic acid (DMA V %) through liquid chromatography and hydride generation atomic absorption spectrometry. Developmental delays were significantly positively associated with the total urinary arsenic concentration, InAs%, and MMA V %, and was significantly negatively associated with DMA V % in a dose-dependent manner. MMA V % was negatively associated with the health-related quality of life (HRQOL-1.19 to-1.46, P < 0.01) and functional performance (-0.82 to-1.14, P < 0.01), whereas DMA V % was positively associated with HRQOL (0.33-0.35, P < 0.05) and functional performance (0.21-0.39, P < 0.01-0.05) in all children and in those with developmental delays. The arsenic methylation capacity is dose-dependently associated with developmental delays and with the health status of children, particularly those with developmental delays.

原文英語
文章編號37287
期刊Scientific Reports
6
DOIs
出版狀態已發佈 - 十一月 17 2016

ASJC Scopus subject areas

  • General

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