Association between white blood cell count and components of metabolic syndrome

Chung Ze Wu, Jiunn D. Lin, Jer Chuan Li, Shi Wen Kuo, Chang Hsun Hsieh, Wei Chen Lian, Chien Hsing Lee, Hsiang Lin Wan, Yi Jen Hung, Dee Pei

研究成果: 雜誌貢獻文章

8 引文 (Scopus)

摘要

Background: Components of metabolic syndrome (MetS) were found to be associated with several inflammatory factors including white blood cell count (WBCC), which is an easily available test in clinical practice. In the present study, the relationships between WBCC and MetS components were investigated in children. Methods: A total of 288 Taiwanese children, under 10 years old, with normal WBCC, were enrolled in the study. They were divided into quartiles according to WBCC (lowest, WBCC1; highest, WBCC4). The mean values of each MetS component for every group were compared in boys and girls separately. Multivariate linear regression between the WBCC and the MetS components after adjusting for age and body mass index (BMI) were also evaluated. Results: In group comparison, only the high-density lipoprotein-cholesterol (HDL-C) was found to be significantly lower in WBCC4 in boys. Other components were not different. After multivariate linear regression, WBCC was negatively correlated to HDL-C and positively to BMI in boys. Although not significant, similar relationships were also observed in girls. Interestingly, borderline positive correlation was noted between triglyceride (TG) and WBCC in girls. Conclusion: BMI was positively and HDL-C was negatively related to WBCC in boys. A similar trend could also be observed in girls but without significance. Borderline significant correlation between TG and WBCC was noted in girls. These findings suggest that cardiovascular risks might commence even in childhood. Early detection of children with these abnormalities may help to prevent cardiovascular disease and diabetes in adolescence or even adulthood.

原文英語
頁(從 - 到)14-18
頁數5
期刊Pediatrics International
51
發行號1
DOIs
出版狀態已發佈 - 二月 2009
對外發佈Yes

指紋

Cellular Structures
Leukocyte Count
HDL Cholesterol
Body Mass Index
Linear Models
Triglycerides
Cardiovascular Diseases

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

引用此文

Association between white blood cell count and components of metabolic syndrome. / Wu, Chung Ze; Lin, Jiunn D.; Li, Jer Chuan; Kuo, Shi Wen; Hsieh, Chang Hsun; Lian, Wei Chen; Lee, Chien Hsing; Wan, Hsiang Lin; Hung, Yi Jen; Pei, Dee.

於: Pediatrics International, 卷 51, 編號 1, 02.2009, p. 14-18.

研究成果: 雜誌貢獻文章

Wu, CZ, Lin, JD, Li, JC, Kuo, SW, Hsieh, CH, Lian, WC, Lee, CH, Wan, HL, Hung, YJ & Pei, D 2009, 'Association between white blood cell count and components of metabolic syndrome', Pediatrics International, 卷 51, 編號 1, 頁 14-18. https://doi.org/10.1111/j.1442-200X.2008.02658.x
Wu, Chung Ze ; Lin, Jiunn D. ; Li, Jer Chuan ; Kuo, Shi Wen ; Hsieh, Chang Hsun ; Lian, Wei Chen ; Lee, Chien Hsing ; Wan, Hsiang Lin ; Hung, Yi Jen ; Pei, Dee. / Association between white blood cell count and components of metabolic syndrome. 於: Pediatrics International. 2009 ; 卷 51, 編號 1. 頁 14-18.
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abstract = "Background: Components of metabolic syndrome (MetS) were found to be associated with several inflammatory factors including white blood cell count (WBCC), which is an easily available test in clinical practice. In the present study, the relationships between WBCC and MetS components were investigated in children. Methods: A total of 288 Taiwanese children, under 10 years old, with normal WBCC, were enrolled in the study. They were divided into quartiles according to WBCC (lowest, WBCC1; highest, WBCC4). The mean values of each MetS component for every group were compared in boys and girls separately. Multivariate linear regression between the WBCC and the MetS components after adjusting for age and body mass index (BMI) were also evaluated. Results: In group comparison, only the high-density lipoprotein-cholesterol (HDL-C) was found to be significantly lower in WBCC4 in boys. Other components were not different. After multivariate linear regression, WBCC was negatively correlated to HDL-C and positively to BMI in boys. Although not significant, similar relationships were also observed in girls. Interestingly, borderline positive correlation was noted between triglyceride (TG) and WBCC in girls. Conclusion: BMI was positively and HDL-C was negatively related to WBCC in boys. A similar trend could also be observed in girls but without significance. Borderline significant correlation between TG and WBCC was noted in girls. These findings suggest that cardiovascular risks might commence even in childhood. Early detection of children with these abnormalities may help to prevent cardiovascular disease and diabetes in adolescence or even adulthood.",
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AU - Lin, Jiunn D.

AU - Li, Jer Chuan

AU - Kuo, Shi Wen

AU - Hsieh, Chang Hsun

AU - Lian, Wei Chen

AU - Lee, Chien Hsing

AU - Wan, Hsiang Lin

AU - Hung, Yi Jen

AU - Pei, Dee

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N2 - Background: Components of metabolic syndrome (MetS) were found to be associated with several inflammatory factors including white blood cell count (WBCC), which is an easily available test in clinical practice. In the present study, the relationships between WBCC and MetS components were investigated in children. Methods: A total of 288 Taiwanese children, under 10 years old, with normal WBCC, were enrolled in the study. They were divided into quartiles according to WBCC (lowest, WBCC1; highest, WBCC4). The mean values of each MetS component for every group were compared in boys and girls separately. Multivariate linear regression between the WBCC and the MetS components after adjusting for age and body mass index (BMI) were also evaluated. Results: In group comparison, only the high-density lipoprotein-cholesterol (HDL-C) was found to be significantly lower in WBCC4 in boys. Other components were not different. After multivariate linear regression, WBCC was negatively correlated to HDL-C and positively to BMI in boys. Although not significant, similar relationships were also observed in girls. Interestingly, borderline positive correlation was noted between triglyceride (TG) and WBCC in girls. Conclusion: BMI was positively and HDL-C was negatively related to WBCC in boys. A similar trend could also be observed in girls but without significance. Borderline significant correlation between TG and WBCC was noted in girls. These findings suggest that cardiovascular risks might commence even in childhood. Early detection of children with these abnormalities may help to prevent cardiovascular disease and diabetes in adolescence or even adulthood.

AB - Background: Components of metabolic syndrome (MetS) were found to be associated with several inflammatory factors including white blood cell count (WBCC), which is an easily available test in clinical practice. In the present study, the relationships between WBCC and MetS components were investigated in children. Methods: A total of 288 Taiwanese children, under 10 years old, with normal WBCC, were enrolled in the study. They were divided into quartiles according to WBCC (lowest, WBCC1; highest, WBCC4). The mean values of each MetS component for every group were compared in boys and girls separately. Multivariate linear regression between the WBCC and the MetS components after adjusting for age and body mass index (BMI) were also evaluated. Results: In group comparison, only the high-density lipoprotein-cholesterol (HDL-C) was found to be significantly lower in WBCC4 in boys. Other components were not different. After multivariate linear regression, WBCC was negatively correlated to HDL-C and positively to BMI in boys. Although not significant, similar relationships were also observed in girls. Interestingly, borderline positive correlation was noted between triglyceride (TG) and WBCC in girls. Conclusion: BMI was positively and HDL-C was negatively related to WBCC in boys. A similar trend could also be observed in girls but without significance. Borderline significant correlation between TG and WBCC was noted in girls. These findings suggest that cardiovascular risks might commence even in childhood. Early detection of children with these abnormalities may help to prevent cardiovascular disease and diabetes in adolescence or even adulthood.

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