Association between VEGF gene promoter polymorphisms and bladder cancer: An updated meta-analysis

Chih Heng Chen, Chen Hsun Ho, Steven Kuan-Hua Huang, Cheng Huang Shen, Chia Chang Wu, Yuan Hung Wang

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)


Background: Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as −2578C/A and −460C/T and bladder cancer risk; however, these results are inconclusive. Therefore, we performed this meta-analysis to investigate the association between VEGF gene promoter polymorphisms and bladder cancer risk. Methods: PubMed, Embase, Cochrane Library and Web of Science databases were searched for studies published before September 2018. The methodological quality assessment of included studies was performed based on the Newcastle-Ottawa Quality Scale (NOS). We conducted a systematic review and meta-analysis using both fixed- and random-effect model. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the relationship. In addition, the stability of our analysis was evaluated by heterogeneity, sensitivity, subgroup of ethnicity, and publication bias analysis. Results: We finally included 7 case-control studies with a total of 2412 bladder cancer patients and 3157 cancer-free controls. In Asian population with the VEGF −2578C/A polymorphism, significantly higher bladder cancer risks of 1.55 (95% CI = 1.25–1.93) and 1.53 (95% CI = 1.11–2.10) were found in the heterozygous model (AC vs CC) and the dominant model (AA + AC vs CC), respectively. Though there was no statistical association between VEGF −460C/T polymorphism and bladder cancer, a tendency to higher bladder cancer risk was observed in various genetic models (T vs C; TT vs CC; TC vs CC and TT + TC vs CC). Conclusions: Our findings suggest that VEGF −2578C/A polymorphism might be a risk factor with a modest significance for bladder cancer only in Asian population. Further studies with a larger sample size and other functional polymorphisms are needed to explore the effects of VEGF gene on the risk of bladder cancer.
出版狀態已發佈 - 7月 2020

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學
  • 生物化學
  • 血液學
  • 分子生物學


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