Association between variants at the GABA(A)β2, GABA(A)α6 and GABA(A)γ2 gene cluster and alcohol dependence in a Scottish population

E. W. Loh, I. Smith, R. Murray, M. McLaughlin, S. McNulty, D. Ball

研究成果: 雜誌貢獻文章

67 引文 (Scopus)

摘要

A role for the GABA/benzodiazepine receptor complex in alcohol dependence syndrome has been suggested by several lines of evidence. To elucidate the role of GABA(A) subunits in human alcohol dependence syndrome, we identified polymorphisms in the GABA(A)β2 and GABA(A)α6 receptor subunit genes on 5q33 and assessed their potential contribution in an association study, together with a Ncλ RFLP at the GABA(A)γ2 receptor subunit gene. One hundred and eight alcohol-dependent subjects and 54 unrelated controls were recruited from Scotland. Two novel genetic markers were identified at the GABA(A)β2 and GABA(A)α6 receptor subunit genes and examined for association with the alcohol dependence syndrome and subgroups of subjects with Korsakoff's psychosis and without Korsakoff's psychosis, together with a Ncλ RFLP at the GABA(A)γ2 receptor subunit gene. The χ2 tests demonstrated associations between all alcohol-dependent subjects (not stratified) and the Banl RFLP at the GABA(A)β2 receptor subunit gene (P = 0.015), and the AlwNI RFLP at the GABA(A)α6 receptor gene (P = 0.013). Significant associations were also found between the alcohol-dependent subjects with Korsakoff's psychosis and the Banl RFLP (P = 0.039) and the AlwNI RFLP (P = 0.003). Haplotype analysis also provided evidence of association when all alcohol-dependent subjects (P = 0.013) and the subjects with Korsakoff's psychosis (P = 0.007) were compared with controls. Our findings provide evidence for a role for the GABA(A) receptor subunit cluster on chromosome 5q33 in susceptibility to the alcohol dependence syndrome and Korsakoff's psychosis.
原文英語
頁(從 - 到)539-544
頁數6
期刊Molecular Psychiatry
4
發行號6
DOIs
出版狀態已發佈 - 一月 1 1999
對外發佈Yes

指紋

GABA-A Receptors
Multigene Family
Korsakoff Syndrome
gamma-Aminobutyric Acid
Alcoholism
Restriction Fragment Length Polymorphisms
Population
Alcohols
Genes
Scotland
Genetic Markers
Haplotypes
Chromosomes

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

引用此文

Association between variants at the GABA(A)β2, GABA(A)α6 and GABA(A)γ2 gene cluster and alcohol dependence in a Scottish population. / Loh, E. W.; Smith, I.; Murray, R.; McLaughlin, M.; McNulty, S.; Ball, D.

於: Molecular Psychiatry, 卷 4, 編號 6, 01.01.1999, p. 539-544.

研究成果: 雜誌貢獻文章

Loh, E. W. ; Smith, I. ; Murray, R. ; McLaughlin, M. ; McNulty, S. ; Ball, D. / Association between variants at the GABA(A)β2, GABA(A)α6 and GABA(A)γ2 gene cluster and alcohol dependence in a Scottish population. 於: Molecular Psychiatry. 1999 ; 卷 4, 編號 6. 頁 539-544.
@article{f8a428230a9641c7bf372d9a1333bc2f,
title = "Association between variants at the GABA(A)β2, GABA(A)α6 and GABA(A)γ2 gene cluster and alcohol dependence in a Scottish population",
abstract = "A role for the GABA/benzodiazepine receptor complex in alcohol dependence syndrome has been suggested by several lines of evidence. To elucidate the role of GABA(A) subunits in human alcohol dependence syndrome, we identified polymorphisms in the GABA(A)β2 and GABA(A)α6 receptor subunit genes on 5q33 and assessed their potential contribution in an association study, together with a Ncλ RFLP at the GABA(A)γ2 receptor subunit gene. One hundred and eight alcohol-dependent subjects and 54 unrelated controls were recruited from Scotland. Two novel genetic markers were identified at the GABA(A)β2 and GABA(A)α6 receptor subunit genes and examined for association with the alcohol dependence syndrome and subgroups of subjects with Korsakoff's psychosis and without Korsakoff's psychosis, together with a Ncλ RFLP at the GABA(A)γ2 receptor subunit gene. The χ2 tests demonstrated associations between all alcohol-dependent subjects (not stratified) and the Banl RFLP at the GABA(A)β2 receptor subunit gene (P = 0.015), and the AlwNI RFLP at the GABA(A)α6 receptor gene (P = 0.013). Significant associations were also found between the alcohol-dependent subjects with Korsakoff's psychosis and the Banl RFLP (P = 0.039) and the AlwNI RFLP (P = 0.003). Haplotype analysis also provided evidence of association when all alcohol-dependent subjects (P = 0.013) and the subjects with Korsakoff's psychosis (P = 0.007) were compared with controls. Our findings provide evidence for a role for the GABA(A) receptor subunit cluster on chromosome 5q33 in susceptibility to the alcohol dependence syndrome and Korsakoff's psychosis.",
keywords = "Alcohol dependence, Chromosome 5, GABA(A) subunit receptor genes, Genetic polymorphisms, Korsakoff's psychosis",
author = "Loh, {E. W.} and I. Smith and R. Murray and M. McLaughlin and S. McNulty and D. Ball",
year = "1999",
month = "1",
day = "1",
doi = "10.1038/sj.mp.4000554",
language = "English",
volume = "4",
pages = "539--544",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Association between variants at the GABA(A)β2, GABA(A)α6 and GABA(A)γ2 gene cluster and alcohol dependence in a Scottish population

AU - Loh, E. W.

AU - Smith, I.

AU - Murray, R.

AU - McLaughlin, M.

AU - McNulty, S.

AU - Ball, D.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - A role for the GABA/benzodiazepine receptor complex in alcohol dependence syndrome has been suggested by several lines of evidence. To elucidate the role of GABA(A) subunits in human alcohol dependence syndrome, we identified polymorphisms in the GABA(A)β2 and GABA(A)α6 receptor subunit genes on 5q33 and assessed their potential contribution in an association study, together with a Ncλ RFLP at the GABA(A)γ2 receptor subunit gene. One hundred and eight alcohol-dependent subjects and 54 unrelated controls were recruited from Scotland. Two novel genetic markers were identified at the GABA(A)β2 and GABA(A)α6 receptor subunit genes and examined for association with the alcohol dependence syndrome and subgroups of subjects with Korsakoff's psychosis and without Korsakoff's psychosis, together with a Ncλ RFLP at the GABA(A)γ2 receptor subunit gene. The χ2 tests demonstrated associations between all alcohol-dependent subjects (not stratified) and the Banl RFLP at the GABA(A)β2 receptor subunit gene (P = 0.015), and the AlwNI RFLP at the GABA(A)α6 receptor gene (P = 0.013). Significant associations were also found between the alcohol-dependent subjects with Korsakoff's psychosis and the Banl RFLP (P = 0.039) and the AlwNI RFLP (P = 0.003). Haplotype analysis also provided evidence of association when all alcohol-dependent subjects (P = 0.013) and the subjects with Korsakoff's psychosis (P = 0.007) were compared with controls. Our findings provide evidence for a role for the GABA(A) receptor subunit cluster on chromosome 5q33 in susceptibility to the alcohol dependence syndrome and Korsakoff's psychosis.

AB - A role for the GABA/benzodiazepine receptor complex in alcohol dependence syndrome has been suggested by several lines of evidence. To elucidate the role of GABA(A) subunits in human alcohol dependence syndrome, we identified polymorphisms in the GABA(A)β2 and GABA(A)α6 receptor subunit genes on 5q33 and assessed their potential contribution in an association study, together with a Ncλ RFLP at the GABA(A)γ2 receptor subunit gene. One hundred and eight alcohol-dependent subjects and 54 unrelated controls were recruited from Scotland. Two novel genetic markers were identified at the GABA(A)β2 and GABA(A)α6 receptor subunit genes and examined for association with the alcohol dependence syndrome and subgroups of subjects with Korsakoff's psychosis and without Korsakoff's psychosis, together with a Ncλ RFLP at the GABA(A)γ2 receptor subunit gene. The χ2 tests demonstrated associations between all alcohol-dependent subjects (not stratified) and the Banl RFLP at the GABA(A)β2 receptor subunit gene (P = 0.015), and the AlwNI RFLP at the GABA(A)α6 receptor gene (P = 0.013). Significant associations were also found between the alcohol-dependent subjects with Korsakoff's psychosis and the Banl RFLP (P = 0.039) and the AlwNI RFLP (P = 0.003). Haplotype analysis also provided evidence of association when all alcohol-dependent subjects (P = 0.013) and the subjects with Korsakoff's psychosis (P = 0.007) were compared with controls. Our findings provide evidence for a role for the GABA(A) receptor subunit cluster on chromosome 5q33 in susceptibility to the alcohol dependence syndrome and Korsakoff's psychosis.

KW - Alcohol dependence

KW - Chromosome 5

KW - GABA(A) subunit receptor genes

KW - Genetic polymorphisms

KW - Korsakoff's psychosis

UR - http://www.scopus.com/inward/record.url?scp=0033220401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033220401&partnerID=8YFLogxK

U2 - 10.1038/sj.mp.4000554

DO - 10.1038/sj.mp.4000554

M3 - Article

C2 - 10578235

AN - SCOPUS:0033220401

VL - 4

SP - 539

EP - 544

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 6

ER -