Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people: A cross-sectional analysis from I-Lan Longitudinal Aging Study

Chun Chin Chang, Chien Yi Hsu, Ting Yung Chang, Po Hsun Huang, Li Kuo Liu, Liang Kung Chen, Jaw Wen Chen, Shing Jong Lin

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old). Assessment of frailty was based on the 'Fried frailty phenotype' criteria, including weight loss, grip strength, exhaustion, slowness and low physical activity. The study population was stratified into quartiles according to UACR levels. Age, body mass index, hypertension, diabetes, systolic blood pressure, insulin resistance, fasting glucose and high-sensitivity C-reactive protein levels were increased with the increment of UACR (P for trend <0.05). The prevalence of prefrailty/frailty and its components increased across the UACR quartiles. A multivariate stepwise logistic regression analysis revealed that UACR was independently associated with the likelihood of prefrailty/frailty (odds ratio 1.13, 95% CI 1.01-1.27). In conclusion, low-grade albuminuria is associated with the increased prevalence of prefrailty/frailty.

原文英語
文章編號39434
期刊Scientific Reports
6
DOIs
出版狀態已發佈 - 十二月 21 2016

指紋

Independent Living
Albuminuria
Longitudinal Studies
Cross-Sectional Studies
Urine
Albumins
Creatinine
Blood Pressure
Hand Strength
C-Reactive Protein
Insulin Resistance
Weight Loss
Fasting
Atherosclerosis
Body Mass Index
Logistic Models
Odds Ratio
Regression Analysis
Exercise
Hypertension

ASJC Scopus subject areas

  • General

引用此文

Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people : A cross-sectional analysis from I-Lan Longitudinal Aging Study. / Chang, Chun Chin; Hsu, Chien Yi; Chang, Ting Yung; Huang, Po Hsun; Liu, Li Kuo; Chen, Liang Kung; Chen, Jaw Wen; Lin, Shing Jong.

於: Scientific Reports, 卷 6, 39434, 21.12.2016.

研究成果: 雜誌貢獻文章

Chang, Chun Chin ; Hsu, Chien Yi ; Chang, Ting Yung ; Huang, Po Hsun ; Liu, Li Kuo ; Chen, Liang Kung ; Chen, Jaw Wen ; Lin, Shing Jong. / Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people : A cross-sectional analysis from I-Lan Longitudinal Aging Study. 於: Scientific Reports. 2016 ; 卷 6.
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abstract = "Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old). Assessment of frailty was based on the 'Fried frailty phenotype' criteria, including weight loss, grip strength, exhaustion, slowness and low physical activity. The study population was stratified into quartiles according to UACR levels. Age, body mass index, hypertension, diabetes, systolic blood pressure, insulin resistance, fasting glucose and high-sensitivity C-reactive protein levels were increased with the increment of UACR (P for trend <0.05). The prevalence of prefrailty/frailty and its components increased across the UACR quartiles. A multivariate stepwise logistic regression analysis revealed that UACR was independently associated with the likelihood of prefrailty/frailty (odds ratio 1.13, 95{\%} CI 1.01-1.27). In conclusion, low-grade albuminuria is associated with the increased prevalence of prefrailty/frailty.",
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