Association between Kawasaki disease and autism: A population-based study in Taiwan

Ho Chang Kuo, Chung Min Wu, Wei Pin Chang, Chun Nan Kuo, Deniz Yeter, Chun Yi Lin, Jei Tsung Pai, Ying Chen Chi, Chia Hsien Lin, Liang Jen Wang, Wei Chiao Chang

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age-and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2, 815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates. Results: The main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95% confidence interval: 0.68-34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up. Conclusion: Our study indicated that patients with Kawasaki disease are not at increased risk of autism.

原文英語
頁(從 - 到)3705-3716
頁數12
期刊International Journal of Environmental Research and Public Health
11
發行號4
DOIs
出版狀態已發佈 - 四月 3 2014

指紋

Mucocutaneous Lymph Node Syndrome
Autistic Disorder
Taiwan
Population
International Classification of Diseases
Cohort Studies
Survival Rate
Databases
Confidence Intervals
Control Groups

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

引用此文

Association between Kawasaki disease and autism : A population-based study in Taiwan. / Kuo, Ho Chang; Wu, Chung Min; Chang, Wei Pin; Kuo, Chun Nan; Yeter, Deniz; Lin, Chun Yi; Pai, Jei Tsung; Chi, Ying Chen; Lin, Chia Hsien; Wang, Liang Jen; Chang, Wei Chiao.

於: International Journal of Environmental Research and Public Health, 卷 11, 編號 4, 03.04.2014, p. 3705-3716.

研究成果: 雜誌貢獻文章

Kuo, Ho Chang ; Wu, Chung Min ; Chang, Wei Pin ; Kuo, Chun Nan ; Yeter, Deniz ; Lin, Chun Yi ; Pai, Jei Tsung ; Chi, Ying Chen ; Lin, Chia Hsien ; Wang, Liang Jen ; Chang, Wei Chiao. / Association between Kawasaki disease and autism : A population-based study in Taiwan. 於: International Journal of Environmental Research and Public Health. 2014 ; 卷 11, 編號 4. 頁 3705-3716.
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abstract = "Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age-and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2, 815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates. Results: The main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95{\%} confidence interval: 0.68-34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up. Conclusion: Our study indicated that patients with Kawasaki disease are not at increased risk of autism.",
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AU - Lin, Chun Yi

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N2 - Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age-and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2, 815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates. Results: The main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95% confidence interval: 0.68-34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up. Conclusion: Our study indicated that patients with Kawasaki disease are not at increased risk of autism.

AB - Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age-and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2, 815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates. Results: The main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95% confidence interval: 0.68-34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up. Conclusion: Our study indicated that patients with Kawasaki disease are not at increased risk of autism.

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