Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction: A cohort study of 10,612 women in Taiwan

Li Chung Chuang, Hui Chi Chen, San Lin You, Ching Yu Lin, Mei Hung Pan, Yi Chun Chou, Chang Yao Hsieh, Chien Jen Chen

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

This study aimed at assessing the association between the type-specific human papillomavirus (HPV) infection and the risk of adenocarcinoma of the rectum and recto-sigmoid junction. A total of 10,612 women aged 30-65 years old were enrolled from seven townships in Taiwan. Cervical cells collected at study entry were tested for 39 types of HPV infection by polymerase chain reactions and HPV blot kit. Newly developed adenocarcinomas of rectum and recto-sigmoid junction were ascertained through computerized linkage with national cancer registry profiles. An increased risk of adenocarcinomas of the rectum and recto-sigmoid junction was observed with HPV infection, showing a hazard ratio [HR] (95% confidence interval [CI]) of 1.99 (0.98-4.04) after adjustment for age and body mass index. The adjusted HR (95% CI) for the infection of HPV types other than 6 and 11 was 2.18 (1.04-4.60). Women with cervical infection of HPV types other than 6 and 11 at study entry may have an increased risk of adenocarcinomas of the rectum and recto-sigmoid junction, which deserves further validation by large-scale studies.
原文英語
頁(從 - 到)2123-2128
頁數6
期刊Cancer Causes and Control
21
發行號12
DOIs
出版狀態已發佈 - 十二月 2010
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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