Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females

C. J. Huang, H. F. Liu, N. Y. Su, Y. W. Hsu, C. H. Yang, C. C. Chen, P. S. Tsai

研究成果: 雜誌貢獻文章同行評審

48 引文 斯高帕斯(Scopus)

摘要

This study examined the association between pressure pain sensitivity and various single nucleotide polymorphisms (SNPs) of humanμ-, κ-, and σ-opioid receptor (i.e. OPRM1, OPRK1, and OPRD1) genes in 72 healthy adult Taiwanese women of Han Chinese race. Pressure pain threshold and tolerance were measured by an algometer and polymorphisms of the opioid receptor genes determined from blood samples. Our data revealed that pressure pain threshold, but not tolerance, in subjects with the minor allele (termed 'GA') genotype of the IVS2+31G>A poly morphism of the OPRM1 gene was significantly higher than those with major allele (termed 'GG') genotype. Neither pressure pain threshold nor tolerance between major and minor alleles of other SNPs of the OPRM1, OPRK1, and OPRD1 genes were significantly different. These data suggest an association between the IVS2+31G>A SNP of the OPRM1 gene and pressure pain sensitivity in healthy adult females.

原文英語
頁(從 - 到)1288-1295
頁數8
期刊Anaesthesia
63
發行號12
DOIs
出版狀態已發佈 - 十二月 2008

ASJC Scopus subject areas

  • 麻醉與疼痛醫學

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