Association between gout and vertigo in a Taiwanese population

Yu Ting Lin, Hui Wen Lin, Yu-Chen Huang, Wen Tsao Ho, Yu Chuan Li, Ting Jui Chen

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

There are reports of an association between benign paroxysmal positional vertigo and hyperuricemia. We sought to determine the risk of vertigo among patients with gout compared with the general population, using a nationwide Taiwanese population-based claims database. Our study cohort consisted of patients with a diagnosis of gout disorders in 2004 (N = 18 773). Four age- and gender-matched controls for every patient in the study cohort were selected using random sampling as the comparison cohort (N = 75 092). All subjects were followed from the date of cohort entry until they developed vertigo or to the end of 2006. Cox proportional hazard regressions were performed to evaluate the 3-year vertigo-free survival rates. Of the total sample, 2563 (incidence, 10.09 per 1000 person-years) had vertigo during the 3-year follow-up period: 570 (incidence, 11.78 per 1000 person-years) from the study cohort and 1993 (incidence, 9.69 per 1000 person-years) from the comparison cohort. The adjusted hazard ratios (HR) of peripheral and central vertigo in patients with gout compared with controls during the 2-3-year follow-up were 1.17 (95% confidence interval [CI] = 1.05-1.29, p = 0.003) and 1.08 (95% CI = 0.86-1.36, p = 0.53), respectively. This is the first population-based study performed to suggest that patients with gout may have an increased risk of peripheral vertigo but not central vertigo. Benign paroxysmal positional vertigo may be the reason for the observed association; however, future studies are required to further ascertain the relationship between gout and the various causes of peripheral vertigo.

原文英語
頁(從 - 到)857-861
頁數5
期刊Journal of Clinical Neuroscience
20
發行號6
DOIs
出版狀態已發佈 - 六月 2013

指紋

Gout
Vertigo
Population
Cohort Studies
Incidence
Confidence Intervals
Hyperuricemia
Survival Rate
Databases

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Medicine(all)

引用此文

Association between gout and vertigo in a Taiwanese population. / Lin, Yu Ting; Lin, Hui Wen; Huang, Yu-Chen; Ho, Wen Tsao; Li, Yu Chuan; Chen, Ting Jui.

於: Journal of Clinical Neuroscience, 卷 20, 編號 6, 06.2013, p. 857-861.

研究成果: 雜誌貢獻文章

Lin, Yu Ting ; Lin, Hui Wen ; Huang, Yu-Chen ; Ho, Wen Tsao ; Li, Yu Chuan ; Chen, Ting Jui. / Association between gout and vertigo in a Taiwanese population. 於: Journal of Clinical Neuroscience. 2013 ; 卷 20, 編號 6. 頁 857-861.
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abstract = "There are reports of an association between benign paroxysmal positional vertigo and hyperuricemia. We sought to determine the risk of vertigo among patients with gout compared with the general population, using a nationwide Taiwanese population-based claims database. Our study cohort consisted of patients with a diagnosis of gout disorders in 2004 (N = 18 773). Four age- and gender-matched controls for every patient in the study cohort were selected using random sampling as the comparison cohort (N = 75 092). All subjects were followed from the date of cohort entry until they developed vertigo or to the end of 2006. Cox proportional hazard regressions were performed to evaluate the 3-year vertigo-free survival rates. Of the total sample, 2563 (incidence, 10.09 per 1000 person-years) had vertigo during the 3-year follow-up period: 570 (incidence, 11.78 per 1000 person-years) from the study cohort and 1993 (incidence, 9.69 per 1000 person-years) from the comparison cohort. The adjusted hazard ratios (HR) of peripheral and central vertigo in patients with gout compared with controls during the 2-3-year follow-up were 1.17 (95{\%} confidence interval [CI] = 1.05-1.29, p = 0.003) and 1.08 (95{\%} CI = 0.86-1.36, p = 0.53), respectively. This is the first population-based study performed to suggest that patients with gout may have an increased risk of peripheral vertigo but not central vertigo. Benign paroxysmal positional vertigo may be the reason for the observed association; however, future studies are required to further ascertain the relationship between gout and the various causes of peripheral vertigo.",
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