Association between Gastroesophageal Reflux Disease and Appendicitis: A Population-Based Case-Control Study

Li Ting Kao, Ming Chieh Tsai, Herng Ching Lin, Cha Ze Lee

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

Appendicitis and gastroesophageal reflux disease (GERD) are both prevalent diseases and might share similar pathological mechanisms. The aim of this study was to investigate the association between GERD and appendicitis using a large population-based dataset. This study used administrative claims data from the Taiwan Longitudinal Health Insurance Database 2005. We identified 7113 patients with appendicitis as cases, and 28452 matched patients without appendicitis as controls. This study revealed that GERD was found in 359 (5.05%) cases and 728 (2.56%) controls (p <0.001). Conditional logistic regression shows that the adjusted odds ratio (OR) of GERD for cases was 2.05 (95% confidence interval (CI): 1.08∼2.33) compared to controls. The adjusted ORs of prior GERD for patients aged 18∼39, 40∼59, and ≥60 years with appendicitis were 1.96 (95% CI: 1.56∼2.47), 2.36 (95% CI: 1.94∼2.88), and 1.71 (95% CI: 1.31∼2.22) than controls, respectively. We concluded that patients with appendicitis had higher odds of prior GERD than those without appendicitis regardless of age group.
原文英語
文章編號22430
期刊Scientific Reports
6
DOIs
出版狀態已發佈 - 三月 2 2016

ASJC Scopus subject areas

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