Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris

Ting Yung Chang, Chien Yi Hsu, Chun Chih Chiu, Ruey Hsing Chou, Hsin Lei Huang, Chin Chou Huang, Hsin Ban Leu, Po Hsun Huang, Jaw Wen Chen, Shing Jong Lin

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Background: Epicardial adipose tissue is associated with coronary artery disease (CAD). Circulating endothelial progenitor cell (EPC) level represents a marker of endothelial dysfunction and vascular health. However, the relationship between epicardial fat and circulating EPC remains unknown. This study aimed to investigate association between echocardiographic epicardial fat thickness (EFT) and circulating EPC level. Hypothesis: Epicardial fat causes inflammation and contributes to progression of CAD. Methods: We enrolled 213 consecutive patients with stable angina, and EFT was determined by echocardiography. Quantification of EPC markers (defined as CD34 +, CD34 + KDR +, CD34 + KDR + CD133 + cells) in peripheral blood samples was used to measure circulating EPCs. All patients were divided into 3 tertiles according to EFT levels: group 1, low tertile of EFT; group 2, middle tertile of EFT; and group 3, high tertile of EFT. Results: Among the 3 groups, CAD disease severity determined by SXscore was negatively correlated with EFT, but the difference did not reach statistical significance (P = 0.066). Additionally, patients in the high and middle tertiles of EFT had higher circulating EPC levels than did those in the low tertile of EFT (P = 0.001 and P < 0.001, respectively). In multivariate analysis, EPC level was significantly associated with echocardiographic EFT (standardized β = −0.233, P = 0.001), independent of multiple covariates. Conclusions: Epicardial adipose tissue is associated with circulating EPC levels. There was a trend between epicardial fat and severity of CAD, though analysis did not reach statistical significance, and this may be attributed to the interaction between several risk factors of CAD.

原文英語
頁(從 - 到)697-703
頁數7
期刊Clinical Cardiology
40
發行號9
DOIs
出版狀態已發佈 - 九月 1 2017

指紋

Stable Angina
Fats
Coronary Artery Disease
Endothelial Progenitor Cells
Adipose Tissue
Blood Vessels
Echocardiography
Multivariate Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此文

Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris. / Chang, Ting Yung; Hsu, Chien Yi; Chiu, Chun Chih; Chou, Ruey Hsing; Huang, Hsin Lei; Huang, Chin Chou; Leu, Hsin Ban; Huang, Po Hsun; Chen, Jaw Wen; Lin, Shing Jong.

於: Clinical Cardiology, 卷 40, 編號 9, 01.09.2017, p. 697-703.

研究成果: 雜誌貢獻文章

Chang, Ting Yung ; Hsu, Chien Yi ; Chiu, Chun Chih ; Chou, Ruey Hsing ; Huang, Hsin Lei ; Huang, Chin Chou ; Leu, Hsin Ban ; Huang, Po Hsun ; Chen, Jaw Wen ; Lin, Shing Jong. / Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris. 於: Clinical Cardiology. 2017 ; 卷 40, 編號 9. 頁 697-703.
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title = "Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris",
abstract = "Background: Epicardial adipose tissue is associated with coronary artery disease (CAD). Circulating endothelial progenitor cell (EPC) level represents a marker of endothelial dysfunction and vascular health. However, the relationship between epicardial fat and circulating EPC remains unknown. This study aimed to investigate association between echocardiographic epicardial fat thickness (EFT) and circulating EPC level. Hypothesis: Epicardial fat causes inflammation and contributes to progression of CAD. Methods: We enrolled 213 consecutive patients with stable angina, and EFT was determined by echocardiography. Quantification of EPC markers (defined as CD34 +, CD34 + KDR +, CD34 + KDR + CD133 + cells) in peripheral blood samples was used to measure circulating EPCs. All patients were divided into 3 tertiles according to EFT levels: group 1, low tertile of EFT; group 2, middle tertile of EFT; and group 3, high tertile of EFT. Results: Among the 3 groups, CAD disease severity determined by SXscore was negatively correlated with EFT, but the difference did not reach statistical significance (P = 0.066). Additionally, patients in the high and middle tertiles of EFT had higher circulating EPC levels than did those in the low tertile of EFT (P = 0.001 and P < 0.001, respectively). In multivariate analysis, EPC level was significantly associated with echocardiographic EFT (standardized β = −0.233, P = 0.001), independent of multiple covariates. Conclusions: Epicardial adipose tissue is associated with circulating EPC levels. There was a trend between epicardial fat and severity of CAD, though analysis did not reach statistical significance, and this may be attributed to the interaction between several risk factors of CAD.",
keywords = "Atherosclerosis, Endothelial Progenitor Cell, Epicardial Fat",
author = "Chang, {Ting Yung} and Hsu, {Chien Yi} and Chiu, {Chun Chih} and Chou, {Ruey Hsing} and Huang, {Hsin Lei} and Huang, {Chin Chou} and Leu, {Hsin Ban} and Huang, {Po Hsun} and Chen, {Jaw Wen} and Lin, {Shing Jong}",
year = "2017",
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doi = "10.1002/clc.22717",
language = "English",
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TY - JOUR

T1 - Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris

AU - Chang, Ting Yung

AU - Hsu, Chien Yi

AU - Chiu, Chun Chih

AU - Chou, Ruey Hsing

AU - Huang, Hsin Lei

AU - Huang, Chin Chou

AU - Leu, Hsin Ban

AU - Huang, Po Hsun

AU - Chen, Jaw Wen

AU - Lin, Shing Jong

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background: Epicardial adipose tissue is associated with coronary artery disease (CAD). Circulating endothelial progenitor cell (EPC) level represents a marker of endothelial dysfunction and vascular health. However, the relationship between epicardial fat and circulating EPC remains unknown. This study aimed to investigate association between echocardiographic epicardial fat thickness (EFT) and circulating EPC level. Hypothesis: Epicardial fat causes inflammation and contributes to progression of CAD. Methods: We enrolled 213 consecutive patients with stable angina, and EFT was determined by echocardiography. Quantification of EPC markers (defined as CD34 +, CD34 + KDR +, CD34 + KDR + CD133 + cells) in peripheral blood samples was used to measure circulating EPCs. All patients were divided into 3 tertiles according to EFT levels: group 1, low tertile of EFT; group 2, middle tertile of EFT; and group 3, high tertile of EFT. Results: Among the 3 groups, CAD disease severity determined by SXscore was negatively correlated with EFT, but the difference did not reach statistical significance (P = 0.066). Additionally, patients in the high and middle tertiles of EFT had higher circulating EPC levels than did those in the low tertile of EFT (P = 0.001 and P < 0.001, respectively). In multivariate analysis, EPC level was significantly associated with echocardiographic EFT (standardized β = −0.233, P = 0.001), independent of multiple covariates. Conclusions: Epicardial adipose tissue is associated with circulating EPC levels. There was a trend between epicardial fat and severity of CAD, though analysis did not reach statistical significance, and this may be attributed to the interaction between several risk factors of CAD.

AB - Background: Epicardial adipose tissue is associated with coronary artery disease (CAD). Circulating endothelial progenitor cell (EPC) level represents a marker of endothelial dysfunction and vascular health. However, the relationship between epicardial fat and circulating EPC remains unknown. This study aimed to investigate association between echocardiographic epicardial fat thickness (EFT) and circulating EPC level. Hypothesis: Epicardial fat causes inflammation and contributes to progression of CAD. Methods: We enrolled 213 consecutive patients with stable angina, and EFT was determined by echocardiography. Quantification of EPC markers (defined as CD34 +, CD34 + KDR +, CD34 + KDR + CD133 + cells) in peripheral blood samples was used to measure circulating EPCs. All patients were divided into 3 tertiles according to EFT levels: group 1, low tertile of EFT; group 2, middle tertile of EFT; and group 3, high tertile of EFT. Results: Among the 3 groups, CAD disease severity determined by SXscore was negatively correlated with EFT, but the difference did not reach statistical significance (P = 0.066). Additionally, patients in the high and middle tertiles of EFT had higher circulating EPC levels than did those in the low tertile of EFT (P = 0.001 and P < 0.001, respectively). In multivariate analysis, EPC level was significantly associated with echocardiographic EFT (standardized β = −0.233, P = 0.001), independent of multiple covariates. Conclusions: Epicardial adipose tissue is associated with circulating EPC levels. There was a trend between epicardial fat and severity of CAD, though analysis did not reach statistical significance, and this may be attributed to the interaction between several risk factors of CAD.

KW - Atherosclerosis

KW - Endothelial Progenitor Cell

KW - Epicardial Fat

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U2 - 10.1002/clc.22717

DO - 10.1002/clc.22717

M3 - Article

C2 - 28464274

AN - SCOPUS:85018970093

VL - 40

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JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 9

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