Association between dopamine receptor D1 A-48G polymorphism and methamphetamine abuse

Hsing Cheng Liu, Chih K. Chen, Sy J. Leu, Hsiao Tein Wu, Shih K. Lin

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)


Several lines of evidence have suggested that substance abuse is mediated by the dopaminergic rewarding system, primarily through the activity of the dopamine receptor D1 (DRD1). The purpose of the present study was to evaluate the association of DRD1 A-48G polymorphism with methamphetamine (MAP) abusers and MAP-induced psychosis patients. A total of 363 MAP abusers and 425 healthy normal controls were enrolled. The structural Diagnostic Interview for Genetic Study was used to evaluate all MAP abusers. The MAP abusers were classified into psychosis (n = 135) and non-psychosis (n = 228) groups. A-48G polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. The results show that male sex and a higher frequency of MAP abuse were the predisposing factors in the development of MAP psychosis. The DRD1 -48G allele frequency in the MAP psychosis group, non-psychosis group and the healthy normal controls was 0.14, 0.18 and 0.16, respectively. No association was found between DRD1 A-48G polymorphism and MAP abuse and MAP psychosis. However, the data provided additional evidence of ethnicity-related differences in the distribution of polymorphism in comparison to previous studies.

頁(從 - 到)226-231
期刊Psychiatry and Clinical Neurosciences
出版狀態已發佈 - 4月 2006

ASJC Scopus subject areas

  • 神經病學(臨床)
  • 精神病學和心理健康
  • 神經科學 (全部)
  • 神經內科


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