Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population

E. W. Loh, N. L.S. Tang, D. T.S. Lee, S. I. Liu, Alfreda Stadlin

研究成果: 雜誌貢獻文章同行評審

25 引文 斯高帕斯(Scopus)

摘要

GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAγ2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed.
原文英語
頁(從 - 到)439-443
頁數5
期刊American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
144
發行號4
DOIs
出版狀態已發佈 - 六月 5 2007
對外發佈

ASJC Scopus subject areas

  • 遺傳學(臨床)
  • 細胞與分子神經科學
  • 精神病學和心理健康

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