Association analysis of dopamine D2-like receptor genes and methamphetamine abuse

Chih Ken Chen, Xun Hu, Shih Ku Lin, Pak C. Sham, El Wui Loh, Tao Li, Robin M. Murray, David M. Ball

研究成果: 雜誌貢獻文章同行評審

40 引文 斯高帕斯(Scopus)

摘要

Objectives: Substance use disorders are familial, and genetic factors explain a substantial degree of their familial aggregation. This study employs an association approach to examine the genetic underpinning of methamphetamine (MAMP) use and MAMP-induced psychosis. Methods: A total of 416 MAMP abusers from a hospital and a detention center in Taipei were interviewed with the Diagnostic Interview for Genetic Study and the Family Interview for Genetic Study. Genetic polymorphisms of D2-like dopamine receptor genes, DRD2 Taql A, DRD3 Ser-9-Gly, and DRD4 exon III variable number of tandem repeats, were compared between: (a) MAMP users as a whole and 435 normal controls, and (b) those 154 individuals with MAMP-induced psychosis and the 252 MAMP users with no psychosis. Results: None of the three markers we studied were associated with predisposition to psychosis among the MAMP abusers. The MAMP abusers had a higher (P = 0.011) prevalence of the seven-repeat allele of DRD4 than normal controls. Conclusions: Chance fluctuations in the frequency of rare alleles and ascertainment differences in the case and control samples cannot be ruled out. Therefore, further studies of the seven-repeat allele in MAMP abusers and controls should be performed before an association can be established.
原文英語
頁(從 - 到)223-226
頁數4
期刊Psychiatric Genetics
14
發行號4
DOIs
出版狀態已發佈 - 十二月 1 2004
對外發佈

ASJC Scopus subject areas

  • 遺傳學(臨床)
  • 精神病學和心理健康
  • 遺傳學
  • 神經科學 (全部)

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