Assessment of image-guided CyberKnife@ radiosurgery for metastatic spine tumors

Jo Ting Tsai, Jia Wei Lin, Wen Ta Chiu, Woei Chyn Chu

研究成果: 雜誌貢獻文章

37 引文 (Scopus)

摘要

Spinal metastases are associated with significant symptoms. From September 2005 to September 2007, 69 consecutive patients with 127 malignant spine metastatic lesions were treated at Wanfang Hospital with CyberKnife@ (CK) radiosurgery. The radiosurgery dose ranged from 10 to 30 Gy (mean 15.5 Gy) prescribed to the 75-85% isodose line that encompassed at least 95% of the tumor volume. We used fiducials as tracking landmarks for CK treatment of the thoracic and lumbar spine. A torso anthropomorphic phantom and GafChromic MD-55 films were used to verify the accuracy of CK radiosurgery and 2D dose distribution, demonstrated high targeting accuracy with 2% average deviation of the measured dose from the estimated dose at the set-up center and less than 5% dose deviation in 2D isodose curve. Visual Analogue Scale and Oswestry Disability Index questionnaires were used to monitor functional outcome after radiosurgery. Local tumor control at 10 months was 96.8%. Mean pain scores decreased significantly from 65 to 30 after treatment (P = 0.001). Functional disability was significantly improved after treatment (P = 0.002). The most common treatment toxicities were nausea and fatigue. In conclusion, CK radiosurgery is a well-tolerated and effective treatment for spine tumors with good local tumor control and a favorable outcome on pain and functional improvement after treatment.

原文英語
頁(從 - 到)119-127
頁數9
期刊Journal of Neuro-Oncology
94
發行號1
DOIs
出版狀態已發佈 - 2009

指紋

Radiosurgery
Spine
Neoplasms
Therapeutics
Pain
Torso
Tumor Burden
Visual Analog Scale
Nausea
Fatigue
Thorax
Neoplasm Metastasis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

引用此文

Assessment of image-guided CyberKnife@ radiosurgery for metastatic spine tumors. / Tsai, Jo Ting; Lin, Jia Wei; Chiu, Wen Ta; Chu, Woei Chyn.

於: Journal of Neuro-Oncology, 卷 94, 編號 1, 2009, p. 119-127.

研究成果: 雜誌貢獻文章

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abstract = "Spinal metastases are associated with significant symptoms. From September 2005 to September 2007, 69 consecutive patients with 127 malignant spine metastatic lesions were treated at Wanfang Hospital with CyberKnife@ (CK) radiosurgery. The radiosurgery dose ranged from 10 to 30 Gy (mean 15.5 Gy) prescribed to the 75-85{\%} isodose line that encompassed at least 95{\%} of the tumor volume. We used fiducials as tracking landmarks for CK treatment of the thoracic and lumbar spine. A torso anthropomorphic phantom and GafChromic MD-55 films were used to verify the accuracy of CK radiosurgery and 2D dose distribution, demonstrated high targeting accuracy with 2{\%} average deviation of the measured dose from the estimated dose at the set-up center and less than 5{\%} dose deviation in 2D isodose curve. Visual Analogue Scale and Oswestry Disability Index questionnaires were used to monitor functional outcome after radiosurgery. Local tumor control at 10 months was 96.8{\%}. Mean pain scores decreased significantly from 65 to 30 after treatment (P = 0.001). Functional disability was significantly improved after treatment (P = 0.002). The most common treatment toxicities were nausea and fatigue. In conclusion, CK radiosurgery is a well-tolerated and effective treatment for spine tumors with good local tumor control and a favorable outcome on pain and functional improvement after treatment.",
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