Assessing late cardiopulmonary function in patients with repaired tetralogy of fallot using exercise cardiopulmonary function test and cardiac magnetic resonance

Ming Chun Yang, Chun An Chen, Hsin Hui Chiu, Ssu Yuan Chen, Jou Kou Wang, Ming Tai Lin, Shuenn Nan Chiu, Chun Wei Lu, Shu Chien Huang, Mei Hwan Wu

研究成果: 雜誌貢獻文章

摘要

Background: Patients with repaired tetralogy of Fallot (TOF) usually experience progressive right ventricle (RV) dysfunction due to pulmonary regurgitation (PR). This could further worsen the cardiopulmonary function. This study aimed to compare the changes in patient exercise cardiopulmonary test and cardiac magnetic resonance imaging, and consider the implication of these changes. Methods: Our study examined repaired TOF patients who underwent cardiopulmonary exercise test (CPET) to obtain maximal (peak oxygen consumption, peak VO2) and submaximal parameters (oxygen uptake efficiency plateau, oxygen uptake efficiency plateau (OUEP), and ratio of minute ventilation to carbon dioxide production, VE/VCO2 slope). Additionally, the hemodynamic statuswas assessed by using cardiacmagnetic resonance. Criteria for exclusion included TOF patients with pulmonary atresia, atrioventricular septal defect, or absence of pulmonary valve syndrome. Results: We enrolled 158 patients whose mean age at repair was 7.8 ± 9.1 years (range 0.1-49.2 years) and the mean patient age at CPETwas 29.5 ± 12.2 years (range 7.0-57.0 years). Severe PR (PR fraction 40%) in 53 patients, moderate in 55, and mild (PR fraction > 20%) in 50 patients were noted. The mean RV end-diastolic volume index (RVEDVi) was 113 ± 35 ml/m2,with 7 patients observed to have a RVEDVi <163ml/m2. The mean left ventricular ejection fraction (LVEF) was 63 ± 8%, left ventricular end-diastolic volume index (LVEDVi) was 65 ± 12 ml/m2, and LVESVi was 25 ± 14 ml/m2. CPET revealed significantly decreased peak VO2 (68.5 ± 14.4% of predicted), and fair OUEP (90.3 ± 14.1% of predicted) and VE/VCO2 slope (27.1 ± 5.3). PR fraction and age at repair were negatively correlated with maximal and submaximal exercise indicators (peak VO2 and OUEP). Left ventricular (LV) function and size were positively correlated with peak VO2 and OUEP. Conclusions: The results of CPET showed that patients with repaired TOF had a lowmaximal exercise capacity (peak VO2), but a fair submaximal exercise capacity (OUEP and VE/VCO2 slope), suggesting limited exercise capability in high intensity circumstances. PR, LV function and age at total repair were the most important determinants of CPET performance.

原文英語
頁(從 - 到)478-484
頁數7
期刊Acta Cardiologica Sinica
31
發行號6
DOIs
出版狀態已發佈 - 十一月 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Yang, M. C., Chen, C. A., Chiu, H. H., Chen, S. Y., Wang, J. K., Lin, M. T., Chiu, S. N., Lu, C. W., Huang, S. C., & Wu, M. H. (2015). Assessing late cardiopulmonary function in patients with repaired tetralogy of fallot using exercise cardiopulmonary function test and cardiac magnetic resonance. Acta Cardiologica Sinica, 31(6), 478-484. https://doi.org/10.6515/ACS20150210A