Artificial neural network for predicting pathological stage of clinically localized prostate cancer in a Taiwanese population

Chih Wei Tsao, Ching Yu Liu, Tai Lung Cha, Sheng Tang Wu, Guang Huan Sun, Dah Shyong Yu, Hong I. Chen, Sun Yran Chang, Shih Chang Chen, Chien Yeh Hsu

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)


Background: We developed an artificial neural network (ANN) model to predict prostate cancer pathological staging in patients prior to when they received radical prostatectomy as this is more effective than logistic regression (LR), or combined use of age, prostate-specific antigen (PSA), body mass index (BMI), digital rectal examination (DRE), trans-rectal ultrasound (TRUS), biopsy Gleason sum, and primary biopsy Gleason grade. Methods: Our study evaluated 299 patients undergoing retro-pubic radical prostatectomy or robotic-assisted laparoscopic radical prostatectomy surgical procedures with pelvic lymph node dissection. The results were intended to predict the pathological stage of prostate cancer (T2 or T3) after radical surgery. The predictive ability of ANN was compared with LR and validation of the 2007 Partin Tables was estimated by the areas under the receiving operating characteristic curve (AUCs). Results: Of the 299 patients we evaluated, 109 (36.45%) displayed prostate cancer with extra-capsular extension (ECE), and 190 (63.55%) displayed organ-confined disease (OCD). LR analysis showed that only PSA and BMI were statistically significant predictors of prostate cancer with capsule invasion. Overall, ANN outperformed LR significantly (0.795±0.023 versus 0.746±0.025, p=0.016). Validation using the current Partin Tables for the participants of our study was assessed, and the predictive capacity of AUC for OCD was 0.695. Conclusion: ANN was superior to LR at predicting OCD in prostate cancer. Compared with the validation of current Partin Tables for the Taiwanese population, the ANN model resulted in larger AUCs and more accurate prediction of the pathologic stage of prostate cancer.

頁(從 - 到)513-518
期刊Journal of the Chinese Medical Association
出版狀態已發佈 - 10月 1 2014

ASJC Scopus subject areas

  • 醫藥 (全部)


深入研究「Artificial neural network for predicting pathological stage of clinically localized prostate cancer in a Taiwanese population」主題。共同形成了獨特的指紋。