Arthrospira Enhances Seroclearance in Patients with Chronic Hepatitis B Receiving Nucleos(t)ide Analogue through Modulation of TNF-α/IFN-γ Profile

Sheng Jie Shiue, Chao Ling Cheng, Han Shiang Shiue, Chun Nan Chen, Sheng Wei Cheng, Li Wei Wu, Ganbolor Jargalsaikhan, Tze Sian Chan, Hsin Yi Lin, Ming Shun Wu

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1 引文 斯高帕斯(Scopus)

摘要

Chronic hepatitis B (CHB) virus infection, causing immune dysfunction and chronic hep-atitis, is one of the leading risk factors for hepatocellular cancer. We investigated how Arthrospira affected hepatitis B surface antigen (HBsAg) reduction in CHB patients under continued nucleos(t)ide analogues (NA). Sixty CHB patients who had been receiving NA for at least one year with unde-tectable HBV DNA were randomized into three groups: control and oral Arthrospira at 3 or 6 g daily add-on therapy groups. Patients were followed up for 6 months. Oral Arthrospira-diet mice were established to investigate the possible immunological mechanism of Arthrospira against HBV. Within 6 months, mean quantitative HBsAg (qHBsAg) decreased in the oral Arthrospira add-on therapy group. Interestingly, interferon gamma (IFN-γ) increased but TNF-α, interleukin 6 (IL-6), hepatic fibrosis, and steatosis decreased in the add-on groups. In mice, Arthrospira enhanced both innate and adaptive immune system, especially natural killer (NK) cell cytotoxicity, B cell activation, and the interleukin 2 (IL-2), IFN-γ immune response. Arthrospira may modulate IL-2-and TNF-α/IFN-γ-mediated B and T cell activation to reduce HBsAg. Also, Arthrospira has the potential to restore immune tolerance and enhance HBsAg seroclearance in CHB patients through promoting T, B, and NK cell activation.
原文英語
文章編號2790
期刊Nutrients
14
發行號14
DOIs
出版狀態已發佈 - 7月 2022

ASJC Scopus subject areas

  • 食品科學
  • 營養與營養學

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